Current understanding of the mechanisms for clearance of apoptotic cells-a fine balance

Lois A. Hawkins, Andrew Devitt

Research output: Contribution to journalArticle

Abstract

Apoptosis is an important cell death mechanism by which multicellular organisms remove unwanted cells. It culminates in a rapid, controlled removal of cell corpses by neighboring or recruited viable cells. Whilst many of the molecular mechanisms that mediate corpse clearance are components of the innate immune system, clearance of apoptotic cells is an anti-inflammatory process. Control of cell death is dependent on competing pro-apoptotic and anti-apoptotic signals. Evidence now suggests a similar balance of competing signals is central to the effective removal of cells, through so called 'eat me' and 'don't eat me' signals. Competing signals are also important for the controlled recruitment of phagocytes to sites of cell death. Consequently recruitment of phagocytes to and from sites of cell death can underlie the resolution or inappropriate propagation of cell death and inflammation. This article highlights our understanding of mechanisms mediating clearance of dying cells and discusses those mechanisms controlling phagocyte migration and how inappropriate control may promote important pathologies. © the authors, publisher and licensee libertas academica limited.

LanguageEnglish
Pages57-68
Number of pages12
JournalJournal of Cell Death
Volume6
Issue number3932
DOIs
Publication statusPublished - 23 Oct 2013

Fingerprint

Cell death
Cells
Cell Death
Phagocytes
Cadaver
Immune system
Pathology
Anti-Inflammatory Agents
Immune System
Apoptosis
Inflammation

Bibliographical note

© the authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons
CC-BY-NC 3.0 License.

Keywords

  • apoptosis
  • apoptotic cell clearance
  • chemotaxis
  • extracellular vesicles
  • phagocyte

Cite this

@article{811175c6e0f547dca7bf77dd1afcbb84,
title = "Current understanding of the mechanisms for clearance of apoptotic cells-a fine balance",
abstract = "Apoptosis is an important cell death mechanism by which multicellular organisms remove unwanted cells. It culminates in a rapid, controlled removal of cell corpses by neighboring or recruited viable cells. Whilst many of the molecular mechanisms that mediate corpse clearance are components of the innate immune system, clearance of apoptotic cells is an anti-inflammatory process. Control of cell death is dependent on competing pro-apoptotic and anti-apoptotic signals. Evidence now suggests a similar balance of competing signals is central to the effective removal of cells, through so called 'eat me' and 'don't eat me' signals. Competing signals are also important for the controlled recruitment of phagocytes to sites of cell death. Consequently recruitment of phagocytes to and from sites of cell death can underlie the resolution or inappropriate propagation of cell death and inflammation. This article highlights our understanding of mechanisms mediating clearance of dying cells and discusses those mechanisms controlling phagocyte migration and how inappropriate control may promote important pathologies. {\circledC} the authors, publisher and licensee libertas academica limited.",
keywords = "apoptosis, apoptotic cell clearance, chemotaxis, extracellular vesicles, phagocyte",
author = "Hawkins, {Lois A.} and Andrew Devitt",
note = "{\circledC} the authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.",
year = "2013",
month = "10",
day = "23",
doi = "10.4137/JCD.S11037",
language = "English",
volume = "6",
pages = "57--68",
journal = "Journal of Cell Death",
issn = "1179-0660",
publisher = "Libertas Academica Ltd.",
number = "3932",

}

Current understanding of the mechanisms for clearance of apoptotic cells-a fine balance. / Hawkins, Lois A.; Devitt, Andrew.

In: Journal of Cell Death, Vol. 6, No. 3932, 23.10.2013, p. 57-68.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Current understanding of the mechanisms for clearance of apoptotic cells-a fine balance

AU - Hawkins, Lois A.

AU - Devitt, Andrew

N1 - © the authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.

PY - 2013/10/23

Y1 - 2013/10/23

N2 - Apoptosis is an important cell death mechanism by which multicellular organisms remove unwanted cells. It culminates in a rapid, controlled removal of cell corpses by neighboring or recruited viable cells. Whilst many of the molecular mechanisms that mediate corpse clearance are components of the innate immune system, clearance of apoptotic cells is an anti-inflammatory process. Control of cell death is dependent on competing pro-apoptotic and anti-apoptotic signals. Evidence now suggests a similar balance of competing signals is central to the effective removal of cells, through so called 'eat me' and 'don't eat me' signals. Competing signals are also important for the controlled recruitment of phagocytes to sites of cell death. Consequently recruitment of phagocytes to and from sites of cell death can underlie the resolution or inappropriate propagation of cell death and inflammation. This article highlights our understanding of mechanisms mediating clearance of dying cells and discusses those mechanisms controlling phagocyte migration and how inappropriate control may promote important pathologies. © the authors, publisher and licensee libertas academica limited.

AB - Apoptosis is an important cell death mechanism by which multicellular organisms remove unwanted cells. It culminates in a rapid, controlled removal of cell corpses by neighboring or recruited viable cells. Whilst many of the molecular mechanisms that mediate corpse clearance are components of the innate immune system, clearance of apoptotic cells is an anti-inflammatory process. Control of cell death is dependent on competing pro-apoptotic and anti-apoptotic signals. Evidence now suggests a similar balance of competing signals is central to the effective removal of cells, through so called 'eat me' and 'don't eat me' signals. Competing signals are also important for the controlled recruitment of phagocytes to sites of cell death. Consequently recruitment of phagocytes to and from sites of cell death can underlie the resolution or inappropriate propagation of cell death and inflammation. This article highlights our understanding of mechanisms mediating clearance of dying cells and discusses those mechanisms controlling phagocyte migration and how inappropriate control may promote important pathologies. © the authors, publisher and licensee libertas academica limited.

KW - apoptosis

KW - apoptotic cell clearance

KW - chemotaxis

KW - extracellular vesicles

KW - phagocyte

UR - http://www.scopus.com/inward/record.url?scp=84886684413&partnerID=8YFLogxK

U2 - 10.4137/JCD.S11037

DO - 10.4137/JCD.S11037

M3 - Article

VL - 6

SP - 57

EP - 68

JO - Journal of Cell Death

T2 - Journal of Cell Death

JF - Journal of Cell Death

SN - 1179-0660

IS - 3932

ER -