Cutting edge: Lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue

David R. Withers*, Fabrina M. Gaspal, Emma C. Mackley, Clare L. Marriott, Ewan A. Ross, Guillaume E. Desanti, Natalie A. Roberts, Andrea J. White, Adriana Flores-Langarica, Fiona M. McConnell, Graham Anderson, Peter J L Lane

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Phylogeny shows that CD4 T cell memory and lymph nodes coevolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR)γ-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian lymph nodes. In this study, we show that although primary CD4 T cell expansion is normal in RORγ-deficient mice, the persistence of memory CD4 T cells is RORγ-dependent. Furthermore, using bone marrow chimeric mice we demonstrate that LTi cells are the key RORγ-expressing cell type sufficient for memory CD4 T cell survival in the absence of persistent Ag. This effect was specific for CD4 T cells, as memory CD8 T cells survived equally well in the presence or absence of LTi cells. These data demonstrate a novel role for LTi cells, archetypal members of the innate lymphoid cell family, in supporting memory CD4 T cell survival in vivo.

Original languageEnglish
Pages (from-to)2094-2098
Number of pages5
JournalJournal of Immunology
Volume189
Issue number5
DOIs
Publication statusPublished - 1 Sep 2012

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    Withers, D. R., Gaspal, F. M., Mackley, E. C., Marriott, C. L., Ross, E. A., Desanti, G. E., Roberts, N. A., White, A. J., Flores-Langarica, A., McConnell, F. M., Anderson, G., & Lane, P. J. L. (2012). Cutting edge: Lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue. Journal of Immunology, 189(5), 2094-2098. https://doi.org/10.4049/jimmunol.1201639