Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding

Luciana Bordin; Cristina Fiore; Francesco Zen; Michael D Coleman; Eugenio Ragazzi; Giulio Clari

doi:10.1111/j.1476-5381.2010.00962.x

Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding

Luciana Bordin, Cristina Fiore, Francesco Zen, Michael D Coleman, Eugenio Ragazzi, Giulio Clari

Research output: Contribution to journal › Article › peer-review

Abstract

N-hydroxylation of dapsone leads to the formation of the toxic hydroxylamines responsible for the clinical methaemoglobinaemia associated with dapsone therapy. Dapsone has been associated with decreased lifespan of erythrocytes, with consequences such as anaemia and morbidity in patients treated with dapsone for malaria. Here, we investigated how dapsone and/or its hydroxylamine derivative (DDS-NHOH) induced erythrocyte membrane alterations that could lead to premature cell removal.

Original language	English
Pages (from-to)	1186-1199
Number of pages	14
Journal	British Journal of Pharmacology
Volume	161
Issue number	5
DOIs	https://doi.org/10.1111/j.1476-5381.2010.00962.x
Publication status	Published - Nov 2010

Keywords

erythrocyte anion exchange protein 1
anti-infective agents
antibodies
dapsone
drug dose-response relationship
erythrocyte membrane
erythrocytes
humans
immunoglobulin G
male
middle aged
phosphorylation
time factors
tyrosine

Access to Document

10.1111/j.1476-5381.2010.00962.x

Cite this

@article{933a308c52914321a7fe319185a6c1b1,

title = "Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding",

abstract = "N-hydroxylation of dapsone leads to the formation of the toxic hydroxylamines responsible for the clinical methaemoglobinaemia associated with dapsone therapy. Dapsone has been associated with decreased lifespan of erythrocytes, with consequences such as anaemia and morbidity in patients treated with dapsone for malaria. Here, we investigated how dapsone and/or its hydroxylamine derivative (DDS-NHOH) induced erythrocyte membrane alterations that could lead to premature cell removal.",

keywords = "erythrocyte anion exchange protein 1, anti-infective agents, antibodies, dapsone, drug dose-response relationship, erythrocyte membrane, erythrocytes, humans, immunoglobulin G, male, middle aged, phosphorylation, time factors, tyrosine",

author = "Luciana Bordin and Cristina Fiore and Francesco Zen and Coleman, {Michael D} and Eugenio Ragazzi and Giulio Clari",

note = "{\textcopyright} 2010 The Authors. British Journal of Pharmacology {\textcopyright} 2010 The British Pharmacological Society.",

year = "2010",

month = nov,

doi = "10.1111/j.1476-5381.2010.00962.x",

language = "English",

volume = "161",

pages = "1186--1199",

journal = "British Journal of Pharmacology",

issn = "1476-5381",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding

AU - Bordin, Luciana

AU - Fiore, Cristina

AU - Zen, Francesco

AU - Coleman, Michael D

AU - Ragazzi, Eugenio

AU - Clari, Giulio

PY - 2010/11

Y1 - 2010/11

N2 - N-hydroxylation of dapsone leads to the formation of the toxic hydroxylamines responsible for the clinical methaemoglobinaemia associated with dapsone therapy. Dapsone has been associated with decreased lifespan of erythrocytes, with consequences such as anaemia and morbidity in patients treated with dapsone for malaria. Here, we investigated how dapsone and/or its hydroxylamine derivative (DDS-NHOH) induced erythrocyte membrane alterations that could lead to premature cell removal.

AB - N-hydroxylation of dapsone leads to the formation of the toxic hydroxylamines responsible for the clinical methaemoglobinaemia associated with dapsone therapy. Dapsone has been associated with decreased lifespan of erythrocytes, with consequences such as anaemia and morbidity in patients treated with dapsone for malaria. Here, we investigated how dapsone and/or its hydroxylamine derivative (DDS-NHOH) induced erythrocyte membrane alterations that could lead to premature cell removal.

KW - erythrocyte anion exchange protein 1

KW - anti-infective agents

KW - antibodies

KW - dapsone

KW - drug dose-response relationship

KW - erythrocyte membrane

KW - erythrocytes

KW - humans

KW - immunoglobulin G

KW - male

KW - middle aged

KW - phosphorylation

KW - time factors

KW - tyrosine

UR - http://www.scopus.com/inward/record.url?scp=77958617530&partnerID=8YFLogxK

U2 - 10.1111/j.1476-5381.2010.00962.x

DO - 10.1111/j.1476-5381.2010.00962.x

M3 - Article

C2 - 20662842

SN - 1476-5381

VL - 161

SP - 1186

EP - 1199

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 5

ER -

Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this