Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding

Luciana Bordin, Cristina Fiore, Francesco Zen, Michael D Coleman, Eugenio Ragazzi, Giulio Clari

Research output: Contribution to journalArticle

Abstract

N-hydroxylation of dapsone leads to the formation of the toxic hydroxylamines responsible for the clinical methaemoglobinaemia associated with dapsone therapy. Dapsone has been associated with decreased lifespan of erythrocytes, with consequences such as anaemia and morbidity in patients treated with dapsone for malaria. Here, we investigated how dapsone and/or its hydroxylamine derivative (DDS-NHOH) induced erythrocyte membrane alterations that could lead to premature cell removal.
LanguageEnglish
Pages1186-1199
Number of pages14
JournalBritish Journal of Pharmacology
Volume161
Issue number5
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Dapsone
Erythrocyte Membrane
Antibodies
Hydroxylamines
Methemoglobinemia
Hydroxylamine
Poisons
Hydroxylation
Malaria
Anemia
Erythrocytes
4-amino-4'-hydroxylaminodiphenylsulfone
Morbidity

Keywords

  • erythrocyte anion exchange protein 1
  • anti-infective agents
  • antibodies
  • dapsone
  • drug dose-response relationship
  • erythrocyte membrane
  • erythrocytes
  • humans
  • immunoglobulin G
  • male
  • middle aged
  • phosphorylation
  • time factors
  • tyrosine

Cite this

Bordin, Luciana ; Fiore, Cristina ; Zen, Francesco ; Coleman, Michael D ; Ragazzi, Eugenio ; Clari, Giulio. / Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding. In: British Journal of Pharmacology. 2010 ; Vol. 161, No. 5. pp. 1186-1199.
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Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding. / Bordin, Luciana; Fiore, Cristina; Zen, Francesco; Coleman, Michael D; Ragazzi, Eugenio; Clari, Giulio.

In: British Journal of Pharmacology, Vol. 161, No. 5, 11.2010, p. 1186-1199.

Research output: Contribution to journalArticle

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AU - Fiore, Cristina

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AU - Coleman, Michael D

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