Deficiencia de vitamina D: ¿Factor de riesgo de síndrome metabólico? Vitamina D y síndrome metabólico

Translated title of the contribution: Association between vitamin D deficiency and metabolic syndrome

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Vitamin D has an essential role in calcium metabolism and bone health. Vitamin
D3 or cholecalciferol is synthesized from 7-dehydrocholesterol or provitamin D3, by sunlight ultraviolet radiation to the skin. 7-dehydrocholesterol is subsequently hydroxylated in the liver and then in the kidney to produce 1,25-(OH)2D3, the active metabolite that binds to specific receptors (VDR) in target tissues, mainly bone and intestine. Other tissues, such as the immune and cardiovascular system, have also VDR. Vitamin D deficiency can induce rickets in children and osteomalacia and osteoporosis in adults. A possible inverse association between vitamin D levels and the prevalence of metabolic syndrome has been proposed. Vitamin D deficiency increases the risk of type 1 diabetes, insulin resistance, and hypertension, key components of this syndrome. However, other studies have not confirmed this association. Further clinical and experimental studies are needed to ascertain the role of vitamin D in metabolic syndrome.
Translated title of the contributionAssociation between vitamin D deficiency and metabolic syndrome
Original languageSpanish
Pages (from-to)1312-1318
Number of pages7
JournalRevista Medica de Chile
Issue number10
Publication statusPublished - 2010

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