TY - JOUR
T1 - Dementia with Lewy bodies
T2 - Clustering of Lewy bodies in human patients
AU - Armstrong, Richard A.
AU - Cairns, Nigel J.
AU - Lantos, Peter L.
PY - 1997/3/7
Y1 - 1997/3/7
N2 - Clustering of Lewy bodies (LB) was studied in four regions of the medial temporal lobe in 12 cases of dementia with LB (DLB). LB exhibited clustering in 67/70 (96%) brain areas analysed. In 34/70 (49%) analyses, LB were present in a single large cluster ≤6400 μm in diameter, in 33/70 (47%) LB occurred in smaller clusters 200-3200 μm in diameter which exhibited a regular periodicity relative to the tissue boundary and in 3/70 (4%), LB were randomly distributed. A regular pattern of LB clusters was observed equally frequently in the cortex and hippocampus, in upper and lower cortical laminae and in 'pure' cases of DLB with negligible Alzheimer's disease (AD) pathology compared with cases of AD with DLB. In cortical regions, there was no significant correlation between LB cluster size in the upper and lower cortical laminae. The regular periodicity of LB clusters suggests that LB develop in relation to the cells of origin of specific cortico-cortical and cortico-hippocampal projections.
AB - Clustering of Lewy bodies (LB) was studied in four regions of the medial temporal lobe in 12 cases of dementia with LB (DLB). LB exhibited clustering in 67/70 (96%) brain areas analysed. In 34/70 (49%) analyses, LB were present in a single large cluster ≤6400 μm in diameter, in 33/70 (47%) LB occurred in smaller clusters 200-3200 μm in diameter which exhibited a regular periodicity relative to the tissue boundary and in 3/70 (4%), LB were randomly distributed. A regular pattern of LB clusters was observed equally frequently in the cortex and hippocampus, in upper and lower cortical laminae and in 'pure' cases of DLB with negligible Alzheimer's disease (AD) pathology compared with cases of AD with DLB. In cortical regions, there was no significant correlation between LB cluster size in the upper and lower cortical laminae. The regular periodicity of LB clusters suggests that LB develop in relation to the cells of origin of specific cortico-cortical and cortico-hippocampal projections.
KW - Alzheimer's disease
KW - clustering
KW - dementia with Lewy bodies
KW - Lewy body
KW - medial temporal lobe
UR - http://www.scopus.com/inward/record.url?scp=0031054431&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S0304394097134516?via%3Dihub
U2 - 10.1016/S0304-3940(97)13451-6
DO - 10.1016/S0304-3940(97)13451-6
M3 - Article
C2 - 9132686
SN - 0304-3940
VL - 224
SP - 41
EP - 44
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -