Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

Corticobasal degeneration (CBD) is a rare, progressive movement disorder characterized neuropathologically by widespread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic inclusions (NCI), oligodendroglial inclusions (GI), and astrocytic plaques (AP). However, ß -amyloid (A ß) deposits have been observed in the cerebral cortex and/or hippocampus in some cases of CBD. To clarify the role of Aß deposition in CBD, the densities and spatial patterns of the Aß deposits were studied in three cases. In two cases, expressing apolipoprotein E (APOE) genotypes 2/3 or 3/3, the densities of the Aß deposits were similar to those in normal elderly brain. In the remaining case, expressing APOE genotype 3/4, Aß deposition was observed throughout the cerebral cortex, sectors CA1 and CA2 of the hippocampus, and the molecular layer of the dentate gyrus. The densities of the Aß deposits in this case were typical of those observed in Alzheimer's disease (AD). In the three cases, clustering of Aß deposits, with clusters ranging in size from 200 to >6400 µm in diameter, was evident in 25/27 (93%) of analyses. In addition, the clusters of Aß deposits were regularly distributed parallel to the tissue boundary in 52% of analyses, a spatial pattern similar to that observed in AD. These results suggest: (1) in some CBD cases, Aß pathology is age-related, (2) more extensive Aß deposition is observed in some cases, the density and spatial patterns of the Aß deposits being similar to AD, and (3) extensive deposition of Aß in CBD may be associated with APOE allele e4.
Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalFolia Neuropathologica
Volume49
Issue number1
Publication statusPublished - 2011

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Amyloid Plaques
Cerebral Cortex
Hippocampus
Alzheimer Disease
Genotype
Apolipoprotein E2
Apolipoprotein E3
Pathology
Spatial Analysis
Inclusion Bodies
Dentate Gyrus
Movement Disorders
Apolipoproteins E
Neuroglia
Cluster Analysis
Alleles
Brain
Alzheimer disease, familial, type 3

Bibliographical note

Creative Commons Attribution Non-Commercial Share Alike International 4.0. Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration
Richard A. Armstrong
Folia Neuropathol 2011; 49 (1): 14-20

Keywords

  • corticobasal degeneration (CBD)
  • β-amyloid (A β)
  • density
  • spatial pattern
  • Alzheimer’s disease (AD)
  • apolipoprotein E (APOE)

Cite this

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title = "Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration",
abstract = "Corticobasal degeneration (CBD) is a rare, progressive movement disorder characterized neuropathologically by widespread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic inclusions (NCI), oligodendroglial inclusions (GI), and astrocytic plaques (AP). However, {\ss} -amyloid (A {\ss}) deposits have been observed in the cerebral cortex and/or hippocampus in some cases of CBD. To clarify the role of A{\ss} deposition in CBD, the densities and spatial patterns of the A{\ss} deposits were studied in three cases. In two cases, expressing apolipoprotein E (APOE) genotypes 2/3 or 3/3, the densities of the A{\ss} deposits were similar to those in normal elderly brain. In the remaining case, expressing APOE genotype 3/4, A{\ss} deposition was observed throughout the cerebral cortex, sectors CA1 and CA2 of the hippocampus, and the molecular layer of the dentate gyrus. The densities of the A{\ss} deposits in this case were typical of those observed in Alzheimer's disease (AD). In the three cases, clustering of A{\ss} deposits, with clusters ranging in size from 200 to >6400 µm in diameter, was evident in 25/27 (93{\%}) of analyses. In addition, the clusters of A{\ss} deposits were regularly distributed parallel to the tissue boundary in 52{\%} of analyses, a spatial pattern similar to that observed in AD. These results suggest: (1) in some CBD cases, A{\ss} pathology is age-related, (2) more extensive A{\ss} deposition is observed in some cases, the density and spatial patterns of the A{\ss} deposits being similar to AD, and (3) extensive deposition of A{\ss} in CBD may be associated with APOE allele e4.",
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Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration. / Armstrong, Richard A.

In: Folia Neuropathologica, Vol. 49, No. 1, 2011, p. 14-20.

Research output: Contribution to journalArticle

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