Desensitisation of adrenomedullin and CGRP receptors

Debbie L. Hay; David R. Poyner; David M. Smith

doi:10.1016/S0167-0115(03)00032-6

Desensitisation of adrenomedullin and CGRP receptors

Debbie L. Hay^*, David R. Poyner, David M. Smith

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts. © 2003 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	139-145
Number of pages	7
Journal	Regulatory peptides
Volume	112
Issue number	1-3
DOIs	https://doi.org/10.1016/S0167-0115(03)00032-6
Publication status	Published - 15 Apr 2003

Keywords

adrenomedullin
CGRP
CRLR
desensitisation
RAMP
rat-2 fibroblast

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10.1016/S0167-0115(03)00032-6

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title = "Desensitisation of adrenomedullin and CGRP receptors",

abstract = "Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts. {\textcopyright} 2003 Elsevier Science B.V. All rights reserved.",

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AU - Hay, Debbie L.

AU - Poyner, David R.

AU - Smith, David M.

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N2 - Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts. © 2003 Elsevier Science B.V. All rights reserved.

AB - Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts. © 2003 Elsevier Science B.V. All rights reserved.

KW - adrenomedullin

KW - CGRP

KW - CRLR

KW - desensitisation

KW - RAMP

KW - rat-2 fibroblast

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SP - 139

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JO - Regulatory peptides

JF - Regulatory peptides

IS - 1-3

ER -

Desensitisation of adrenomedullin and CGRP receptors

Abstract

Keywords

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