Desensitisation of adrenomedullin and CGRP receptors

Debbie L. Hay*, David R. Poyner, David M. Smith

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts. © 2003 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalRegulatory peptides
Volume112
Issue number1-3
DOIs
Publication statusPublished - 15 Apr 2003

Keywords

  • adrenomedullin
  • CGRP
  • CRLR
  • desensitisation
  • RAMP
  • rat-2 fibroblast

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