Design and modelling of a micro fluid filter for separating spermatogenic cells

Xianghong Ma*, Mark Prince, Mike Ward, Peter Docker

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The small size of microfabricated structures are opening new avenues in the field of biomedical engineering where structures are being developed to process [1] and analyze[2,3] nanolitre quantities of biological fluids, and cellular tissues. This paper outlines the design and manufacture principals of a passive micro-mechatronic device for the filtration and sorting of spermatogenic cells. This device is to be applied in a urological clinical environment where it can be used to semiautomate the spermatozoa selection process from nonobstructive azoospermic testis biopsies. Detailed and discussed herein are the advantages and drawbacks of Micro-ElectroMechanical Systems (MEMS) as applied to clinical biomedical situations, and requirements for the design methodology and process of a microfluidic system based on MEMS technology with a view to manufacture by Deep Reactive Ion Etching process. The modelling of the micro device using computational fluid dynamic simulation methods is also covered in this paper. MEMS, biomedical, urology, testicular biopsy, microfluid

Original languageEnglish
Title of host publicationProceedings of the ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference - DETC2005
PublisherASME
Pages475-480
Number of pages6
Volume7 A
ISBN (Print)0791847446, 9780791847442
Publication statusPublished - 1 Dec 2005
EventDETC2005: ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference - Long Beach, CA, United Kingdom
Duration: 24 Sep 200528 Sep 2005

Conference

ConferenceDETC2005: ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
CountryUnited Kingdom
CityLong Beach, CA
Period24/09/0528/09/05

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  • Cite this

    Ma, X., Prince, M., Ward, M., & Docker, P. (2005). Design and modelling of a micro fluid filter for separating spermatogenic cells. In Proceedings of the ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference - DETC2005 (Vol. 7 A, pp. 475-480). ASME.