TY - JOUR
T1 - Desynchronizing effect of high-frequency stimulation in a generic cortical network model
AU - Schütt, Markus
AU - Claussen, Jens Christian
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Transcranial electrical stimulation (TCES) and deep brain stimulation are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most pronounced effects around 100 Hz. We apply superthreshold electrical stimulation, specifically depolarizing DC current, interrupted at different frequencies, to a simple model of a population of cortical neurons which uses phenomenological descriptions of neurons by Izhikevich and synaptic connections on a similar level of sophistication. With this model, we are able to reproduce the optimal desynchronization around 100 Hz, as well as to predict the full frequency dependence of the efficiency of desynchronization, and thereby to give a possible explanation for the action mechanism of TCES.
AB - Transcranial electrical stimulation (TCES) and deep brain stimulation are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most pronounced effects around 100 Hz. We apply superthreshold electrical stimulation, specifically depolarizing DC current, interrupted at different frequencies, to a simple model of a population of cortical neurons which uses phenomenological descriptions of neurons by Izhikevich and synaptic connections on a similar level of sophistication. With this model, we are able to reproduce the optimal desynchronization around 100 Hz, as well as to predict the full frequency dependence of the efficiency of desynchronization, and thereby to give a possible explanation for the action mechanism of TCES.
KW - Deep brain stimulation
KW - Desynchronization
KW - High-frequency stimulation
KW - Izhikevich model
KW - Transcranial electrical stimulation
UR - http://www.scopus.com/inward/record.url?scp=84865750074&partnerID=8YFLogxK
UR - https://link.springer.com/article/10.1007%2Fs11571-012-9199-8
U2 - 10.1007/s11571-012-9199-8
DO - 10.1007/s11571-012-9199-8
M3 - Article
AN - SCOPUS:84865750074
SN - 1871-4080
VL - 6
SP - 343
EP - 351
JO - Cognitive Neurodynamics
JF - Cognitive Neurodynamics
IS - 4
ER -