Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies

Irina N. Makovik*, Andrey V. Dunaev, Victor V. Dremin, Alexander I. Krupatkin, Viktor V. Sidorov, Lyudmila S. Khakhicheva, Vadim F. Muradyan, Olga V. Pilipenko, Ilya E. Rafailov, Karina S. Litvinova

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The evaluation of the microcirculatory bed functional state and the identification of angiospastic disorders with related complications, when the pathological changes are reversible, have an important role in medical practice. The aim of this study was to evaluate the possibility of using optical noninvasive methods and the cold pressor test to solve this problem. A total of 33 patients with rheumatological diseases and 32 healthy volunteers were included in the study. Laser Doppler flowmetry, tissue reflectance oximetry and pulse oximetry were used as optical noninvasive methods. The parameters were recorded before, immediately after and 20(Formula presented.)min after the cold pressor test. Based on the measured parameters, the complex parameters of the microcirculatory bed were calculated. A detailed statistical analysis of the parameter changes for each individual in the two groups displayed diverse microcirculatory bed parameter responses upon cold exposure, with differing recovery of parameters after CPT. New diagnostic criteria were proposed for the identification of angiospastic disorders. According to the proposed criteria, 27 people of the volunteers group were confirmed to not display any disorders. In the patient group, however, 18 people were observed to have a relatively normal functional state of the microcirculatory bed, while 15 people were observed to have a possible tendency to angiospasm. To highlight the differences between a relatively normal state and presence of angiospastic disorders, statistical analysis of experimental data was carried out, which revealed significant differences. Further analysis of data with angiospastic disorders identified a relationship between their diagnoses and the results of laboratory studies. Thus, the evaluation of combined noninvasive optical diagnostic method use, the cold pressor test and proposed diagnostic criteria showed a positive result. This approach can be used to detect the presence of possible angiospastic disorders and related complications, as well as microcirculatory bed disorders against the background of other diseases.

Original languageEnglish
Article number1750016
Number of pages15
JournalJournal of Innovative Optical Health Sciences
Issue number1
Publication statusPublished - 9 Jun 2017

Bibliographical note

© The Author(s). This is an Open Access article published by World Scientific Publishing Company. It is distributed under the terms of the Creative Commons Attribution 4.0 (CC-BY) License. Further distribution of this work is permitted, provided the original work is properly cited.


  • angiospasm
  • cold pressor test
  • laser Doppler flowmetry
  • microcirculatory bed
  • noninvasive diagnostics
  • pulse oximetry
  • tissue reflectance oximetry


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