Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications

Karan S. Rana, Lucas Pereira De Souza, Mark A. Isaacs, Farah N. S. Raja, Alexander P. Morrell, Richard A Martin

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.
Original languageEnglish
Pages (from-to)3425-3432
JournalACS Biomaterials Science and Engineering
Volume3
Issue number12
Early online date22 Sep 2017
DOIs
Publication statusPublished - 11 Dec 2017

Bibliographical note

Copyright © 2017 American Chemical Society. This is the accepted author manuscript.

Funding: Osteosarcoma UK.

Keywords

  • apatite; bioactive glass; bone; cancer; gallium; sarcoma

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