Abstract
In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.
| Original language | English |
|---|---|
| Pages (from-to) | 3425-3432 |
| Journal | ACS Biomaterials Science and Engineering |
| Volume | 3 |
| Issue number | 12 |
| Early online date | 22 Sept 2017 |
| DOIs | |
| Publication status | Published - 11 Dec 2017 |
Bibliographical note
Copyright © 2017 American Chemical Society. This is the accepted author manuscript.Funding: Osteosarcoma UK.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- apatite; bioactive glass; bone; cancer; gallium; sarcoma
Fingerprint
Dive into the research topics of 'Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver