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Funding: This manuscript summarizes independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research programme (RP-PG-1211-20016). ES additionally receives support from the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley Foundation Trust (IS-BRC-1215-20018), the NIHR through a Senior Investigator Award (NF-SI-0514-10073), the European Union Innovative Medicines Initiative (EU-IMI 115300), Autistica (7237), Medical Research Council (MR/R000832/1, MR/P019293/1), the Economic and Social Research Council (ESRC 003041/1), Guy’s and St Thomas’ Charitable Foundation (GSTT EF1150502) and the Maudsley Charity.