Development of a Region-Specific Physiologically Based Pharmacokinetic Brain Model to Assess Hippocampus and Frontal Cortex Pharmacokinetics

Keyphrases

• Hippocampus 100%
• Frontal Cortex 100%
• Pharmacokinetics 100%
• Human Pharmacokinetics 100%
• Brain Model 100%
• Development of a Region 100%
• Drug Concentration 66%
• Model Prediction 66%
• Physiologically-based Pharmacokinetic Model 66%
• Brain Compartments 66%
• Brain Regions 33%
• Brain Tissue 33%
• Human Brain 33%
• Coefficient of Variation 33%
• Drug Discovery 33%
• Drug Development 33%
• Morphine 33%
• Blood-brain Barrier 33%
• Predicted No Effect Concentration 33%
• Carbamazepine 33%
• Cerebrospinal Fluid 33%
• Brain Fluids 33%
• Central Nervous System Drugs 33%
• Phenytoin 33%
• Prediction Approach 33%
• Pharmacokinetic Modeling 33%
• Drug Exposure 33%
• Forward Prediction 33%
• Brain Tissue Volume 33%
• CNS Drugs 33%
• Compartment Volumes 33%

Neuroscience

• Frontal Lobe 100%
• Hippocampus 100%
• Pharmacokinetics 100%
• Central Nervous System 20%
• Blood Brain Barrier 20%
• Phenytoin 20%
• Carbamazepine 20%
• Morphine 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Pharmacokinetics 100%
• Drug Concentration 50%
• Drug Development 25%
• Drug Discovery 25%
• Morphine 25%
• Carbamazepine 25%
• Pharmacokinetic Modeling 25%
• Central Nervous System Drug 25%
• Blood-Brain Barrier 25%
• Phenytoin 25%