Development of a solid dosage platform for the oral delivery of bilayer vesicles

Jitinder S. Wilkhu, Sarah E. Mcneil, David E. Anderson, Marc Kirchmeier, Yvonne Perrie*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10% mannitol and 10% dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.
Original languageEnglish
JournalEuropean Journal of Pharmaceutical Sciences
Volumein press
DOIs
Publication statusPublished - 12 Jun 2017

Fingerprint

Tablets
Mannitol
Dextrans
Antigens
Vaccines
Trehalose
Fluid Therapy
Excipients
Dosage Forms
Hardness
Liposomes
Capsules

Bibliographical note

© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).

Funding: BBSRC Industrial Case studentship (BB/G017948/1).

Keywords

  • liposomes
  • oral vaccines
  • niosomes
  • vesicles
  • oral disintegrating tablets

Cite this

Wilkhu, Jitinder S. ; Mcneil, Sarah E. ; Anderson, David E. ; Kirchmeier, Marc ; Perrie, Yvonne. / Development of a solid dosage platform for the oral delivery of bilayer vesicles. In: European Journal of Pharmaceutical Sciences. 2017 ; Vol. in press.
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Development of a solid dosage platform for the oral delivery of bilayer vesicles. / Wilkhu, Jitinder S.; Mcneil, Sarah E.; Anderson, David E.; Kirchmeier, Marc; Perrie, Yvonne.

In: European Journal of Pharmaceutical Sciences, Vol. in press, 12.06.2017.

Research output: Contribution to journalArticle

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