Developmental Divergence of Structural Brain Networks as an Indicator of Future Cognitive Impairments in Childhood Brain Injury: Executive Functions

Daniel J. King, Stefano Seri, Richard Beare, Cathy Catroppa, Vicki A. Anderson, Amanda G. Wood*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Brain insults during childhood can perturb the already non-linear trajectory of typical brain maturation. The diffuse effects of injury can be modelled using structural covariance networks (SCN), which change as a function of neurodevelopment. However, SCNs are estimated at the group-level, limiting applicability to predicting individual-subject outcomes. This study aimed to measure the divergence of the brain networks in paediatric traumatic brain injury (pTBI) patients and controls, and investigate relationships with executive functioning (EF) at 24 months post-injury. T1-weighted MRI acquired acutely in 78 child survivors of pTBI and 33 controls underwent 3D-tissue segmentation to estimate cortical thickness (CT) across 68 atlas-based regions-of-interest (ROIs). Using an ‘add-one-patient’ approach, we estimate a developmental divergence index (DDI). Our approach adopts a novel analytic framework in which age-appropriate reference networks to calculate the DDI were generated from control participants from the ABIDE dataset using a sliding-window approach. Divergence from the age-appropriate SCN was related to reduced EF performance and an increase in behaviours related to executive dysfunctions. The DDI measure showed predictive value with regard to executive functions, highlighting that early imaging can assist in prognosis for cognition.
Original languageEnglish
Article number100762
JournalDevelopmental Cognitive Neuroscience
Volume42
Early online date21 Jan 2020
DOIs
Publication statusE-pub ahead of print - 21 Jan 2020

Fingerprint

Executive Function
Brain Injuries
Brain
Pediatrics
Atlases
Wounds and Injuries
Cognition
Survivors
Cognitive Dysfunction
Traumatic Brain Injury

Bibliographical note

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Funding: European Research Council (ERC) - Consolidator Grant (ERC-CoG) [grant number 682734].

Keywords

  • Child
  • Development
  • Executive function
  • MRI
  • Morphometry
  • Paediatric
  • Structural covariance networks
  • Traumatic brain injury

Cite this

King, Daniel J. ; Seri, Stefano ; Beare, Richard ; Catroppa, Cathy ; Anderson, Vicki A. ; Wood, Amanda G. / Developmental Divergence of Structural Brain Networks as an Indicator of Future Cognitive Impairments in Childhood Brain Injury: Executive Functions. In: Developmental Cognitive Neuroscience. 2020 ; Vol. 42.
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Developmental Divergence of Structural Brain Networks as an Indicator of Future Cognitive Impairments in Childhood Brain Injury: Executive Functions. / King, Daniel J.; Seri, Stefano; Beare, Richard; Catroppa, Cathy; Anderson, Vicki A.; Wood, Amanda G.

In: Developmental Cognitive Neuroscience, Vol. 42, 100762, 04.2020.

Research output: Contribution to journalArticle

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AU - Wood, Amanda G.

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