Diagnosis and management of hereditary renal cell cancer

Fred H. Menko; Eamonn R. Maher

doi:10.1007/978-3-319-29998-3_6

Diagnosis and management of hereditary renal cell cancer

Fred H. Menko^*
, Eamonn R. Maher

^*Corresponding author for this work

Aston Medical School

Surgical Innovations Group at the Netherlands Cancer Institute

Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

13 Citations (Scopus)

Abstract

Renal cell cancer (RCC) is the common denominator for a heterogeneous group of diseases. The subclassification of these tumours is based on histological type and molecular pathogenesis. Insight into molecular pathogenesis has led to the development of targeted systemic therapies. Genetic susceptibility is the principal cause of RCC in about 2–4 % of cases. Hereditary RCC is the umbrella term for about a dozen different conditions, the most frequent of which is von Hippel– Lindau disease. Here, we describe the main hereditary RCC syndromes, consider criteria for referral of RCC patients for clinical genetic assessment and discuss management options for patients with hereditary RCC and their at-risk relatives.

Original language	English
Title of host publication	Rare Hereditary Cancers
Editors	G. Pichert, C. Jacobs
Publisher	Springer
Pages	85-104
Number of pages	20
Volume	205
ISBN (Electronic)	978-3-319-29998-3
ISBN (Print)	978-3-319-29996-9
DOIs	https://doi.org/10.1007/978-3-319-29998-3_6
Publication status	Published - 14 Apr 2016

Publication series

Name	Recent Results in Cancer Research
Publisher	Springer
ISSN (Print)	0080-0015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hereditary
Management
Molecular pathogenesis
Renal cell cancer

Access to Document

10.1007/978-3-319-29998-3_6

Cite this

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title = "Diagnosis and management of hereditary renal cell cancer",

abstract = "Renal cell cancer (RCC) is the common denominator for a heterogeneous group of diseases. The subclassification of these tumours is based on histological type and molecular pathogenesis. Insight into molecular pathogenesis has led to the development of targeted systemic therapies. Genetic susceptibility is the principal cause of RCC in about 2–4 \% of cases. Hereditary RCC is the umbrella term for about a dozen different conditions, the most frequent of which is von Hippel– Lindau disease. Here, we describe the main hereditary RCC syndromes, consider criteria for referral of RCC patients for clinical genetic assessment and discuss management options for patients with hereditary RCC and their at-risk relatives.",

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TY - CHAP

T1 - Diagnosis and management of hereditary renal cell cancer

AU - Menko, Fred H.

AU - Maher, Eamonn R.

PY - 2016/4/14

Y1 - 2016/4/14

N2 - Renal cell cancer (RCC) is the common denominator for a heterogeneous group of diseases. The subclassification of these tumours is based on histological type and molecular pathogenesis. Insight into molecular pathogenesis has led to the development of targeted systemic therapies. Genetic susceptibility is the principal cause of RCC in about 2–4 % of cases. Hereditary RCC is the umbrella term for about a dozen different conditions, the most frequent of which is von Hippel– Lindau disease. Here, we describe the main hereditary RCC syndromes, consider criteria for referral of RCC patients for clinical genetic assessment and discuss management options for patients with hereditary RCC and their at-risk relatives.

AB - Renal cell cancer (RCC) is the common denominator for a heterogeneous group of diseases. The subclassification of these tumours is based on histological type and molecular pathogenesis. Insight into molecular pathogenesis has led to the development of targeted systemic therapies. Genetic susceptibility is the principal cause of RCC in about 2–4 % of cases. Hereditary RCC is the umbrella term for about a dozen different conditions, the most frequent of which is von Hippel– Lindau disease. Here, we describe the main hereditary RCC syndromes, consider criteria for referral of RCC patients for clinical genetic assessment and discuss management options for patients with hereditary RCC and their at-risk relatives.

KW - Hereditary

KW - Management

KW - Molecular pathogenesis

KW - Renal cell cancer

UR - https://www.scopus.com/pages/publications/84977764796

UR - https://link.springer.com/chapter/10.1007/978-3-319-29998-3_6

U2 - 10.1007/978-3-319-29998-3_6

DO - 10.1007/978-3-319-29998-3_6

M3 - Chapter (peer-reviewed)

C2 - 27075350

AN - SCOPUS:84977764796

SN - 978-3-319-29996-9

VL - 205

T3 - Recent Results in Cancer Research

SP - 85

EP - 104

BT - Rare Hereditary Cancers

A2 - Pichert, G.

A2 - Jacobs, C.

PB - Springer

ER -

Diagnosis and management of hereditary renal cell cancer

Abstract

Publication series

UN SDGs

Keywords

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