Diffusing-wave polarimetry for tissue diagnostics

Callum Macdonald; Alexander Doronin; Adrian F. Peña; Michael Eccles; Igor Meglinski

doi:10.1117/12.2038658

Diffusing-wave polarimetry for tissue diagnostics

Callum Macdonald, Alexander Doronin, Adrian F. Peña, Michael Eccles, Igor Meglinski^*

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

Abstract

We exploit the directional awareness of circularly and/or elliptically polarized light propagating within media which exhibit high numbers of scattering events. By tracking the Stokes vector of the detected light on the Poincaŕe sphere, we demonstrate its applicability for characterization of anisotropy of scattering. A phenomenological model is shown to have an excellent agreement with the experimental data and with the results obtained by the polarization tracking Monte Carlo model, developed in house. By analogy to diffusing-wave spectroscopy we call this approach diffusing-wave polarimetry, and illustrate its utility in probing cancerous and non-cancerous tissue samplesin vitro for diagnostic purposes.

Original language	English
Article number	894007
Journal	Proceedings of SPIE - International Society for Optical Engineering
Volume	8940
DOIs	https://doi.org/10.1117/12.2038658
Publication status	Published - 17 Mar 2014
Event	Optical Biopsy XII - San Francisco, CA, United States Duration: 4 Feb 2014 → 5 Feb 2014

Bibliographical note

Copyright 2014 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Keywords

Cancer diagnostics
Circular polarization
Helicity
Monte Carlo
Optical biopsy
Poincaré sphere
Polarimetry
Stokes vector

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title = "Diffusing-wave polarimetry for tissue diagnostics",

abstract = "We exploit the directional awareness of circularly and/or elliptically polarized light propagating within media which exhibit high numbers of scattering events. By tracking the Stokes vector of the detected light on the Poinca{\'r}e sphere, we demonstrate its applicability for characterization of anisotropy of scattering. A phenomenological model is shown to have an excellent agreement with the experimental data and with the results obtained by the polarization tracking Monte Carlo model, developed in house. By analogy to diffusing-wave spectroscopy we call this approach diffusing-wave polarimetry, and illustrate its utility in probing cancerous and non-cancerous tissue samplesin vitro for diagnostic purposes.",

keywords = "Cancer diagnostics, Circular polarization, Helicity, Monte Carlo, Optical biopsy, Poincar{\'e} sphere, Polarimetry, Stokes vector",

author = "Callum Macdonald and Alexander Doronin and Pe{\~n}a, {Adrian F.} and Michael Eccles and Igor Meglinski",

note = "Copyright 2014 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. ; Optical Biopsy XII ; Conference date: 04-02-2014 Through 05-02-2014",

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T1 - Diffusing-wave polarimetry for tissue diagnostics

AU - Macdonald, Callum

AU - Doronin, Alexander

AU - Peña, Adrian F.

AU - Eccles, Michael

AU - Meglinski, Igor

N1 - Copyright 2014 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

PY - 2014/3/17

Y1 - 2014/3/17

N2 - We exploit the directional awareness of circularly and/or elliptically polarized light propagating within media which exhibit high numbers of scattering events. By tracking the Stokes vector of the detected light on the Poincaŕe sphere, we demonstrate its applicability for characterization of anisotropy of scattering. A phenomenological model is shown to have an excellent agreement with the experimental data and with the results obtained by the polarization tracking Monte Carlo model, developed in house. By analogy to diffusing-wave spectroscopy we call this approach diffusing-wave polarimetry, and illustrate its utility in probing cancerous and non-cancerous tissue samplesin vitro for diagnostic purposes.

AB - We exploit the directional awareness of circularly and/or elliptically polarized light propagating within media which exhibit high numbers of scattering events. By tracking the Stokes vector of the detected light on the Poincaŕe sphere, we demonstrate its applicability for characterization of anisotropy of scattering. A phenomenological model is shown to have an excellent agreement with the experimental data and with the results obtained by the polarization tracking Monte Carlo model, developed in house. By analogy to diffusing-wave spectroscopy we call this approach diffusing-wave polarimetry, and illustrate its utility in probing cancerous and non-cancerous tissue samplesin vitro for diagnostic purposes.

KW - Cancer diagnostics

KW - Circular polarization

KW - Helicity

KW - Monte Carlo

KW - Optical biopsy

KW - Poincaré sphere

KW - Polarimetry

KW - Stokes vector

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UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8940/1/Diffusing-wave-polarimetry-for-tissue-diagnostics/10.1117/12.2038658.full

U2 - 10.1117/12.2038658

DO - 10.1117/12.2038658

M3 - Conference article

AN - SCOPUS:84901750737

SN - 0277-786X

VL - 8940

JO - Proceedings of SPIE - International Society for Optical Engineering

JF - Proceedings of SPIE - International Society for Optical Engineering

M1 - 894007

T2 - Optical Biopsy XII

Y2 - 4 February 2014 through 5 February 2014

ER -

Diffusing-wave polarimetry for tissue diagnostics

Abstract

Bibliographical note

Keywords

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