Diffusing-wave polarimetry for tissue diagnostics

Callum Macdonald, Alexander Doronin, Adrian F. Peña, Michael Eccles, Igor Meglinski*

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

We exploit the directional awareness of circularly and/or elliptically polarized light propagating within media which exhibit high numbers of scattering events. By tracking the Stokes vector of the detected light on the Poincaŕe sphere, we demonstrate its applicability for characterization of anisotropy of scattering. A phenomenological model is shown to have an excellent agreement with the experimental data and with the results obtained by the polarization tracking Monte Carlo model, developed in house. By analogy to diffusing-wave spectroscopy we call this approach diffusing-wave polarimetry, and illustrate its utility in probing cancerous and non-cancerous tissue samplesin vitro for diagnostic purposes.

Original languageEnglish
Article number894007
JournalProceedings of SPIE - International Society for Optical Engineering
Volume8940
DOIs
Publication statusPublished - 17 Mar 2014
EventOptical Biopsy XII - San Francisco, CA, United States
Duration: 4 Feb 20145 Feb 2014

Fingerprint

Polarimetry
Polarimeters
polarimetry
Diagnostics
Scattering
Tissue
Light
Anisotropy
Light polarization
Stokes
scattering
polarized light
Analogy
Spectroscopy
Spectrum Analysis
Polarization
Experimental Data
anisotropy
polarization
Model

Bibliographical note

Copyright 2014 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Keywords

  • Cancer diagnostics
  • Circular polarization
  • Helicity
  • Monte Carlo
  • Optical biopsy
  • Poincaré sphere
  • Polarimetry
  • Stokes vector

Cite this

Macdonald, Callum ; Doronin, Alexander ; Peña, Adrian F. ; Eccles, Michael ; Meglinski, Igor. / Diffusing-wave polarimetry for tissue diagnostics. In: Proceedings of SPIE - International Society for Optical Engineering. 2014 ; Vol. 8940.
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Diffusing-wave polarimetry for tissue diagnostics. / Macdonald, Callum; Doronin, Alexander; Peña, Adrian F.; Eccles, Michael; Meglinski, Igor.

In: Proceedings of SPIE - International Society for Optical Engineering, Vol. 8940, 894007, 17.03.2014.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Diffusing-wave polarimetry for tissue diagnostics

AU - Macdonald, Callum

AU - Doronin, Alexander

AU - Peña, Adrian F.

AU - Eccles, Michael

AU - Meglinski, Igor

N1 - Copyright 2014 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

PY - 2014/3/17

Y1 - 2014/3/17

N2 - We exploit the directional awareness of circularly and/or elliptically polarized light propagating within media which exhibit high numbers of scattering events. By tracking the Stokes vector of the detected light on the Poincaŕe sphere, we demonstrate its applicability for characterization of anisotropy of scattering. A phenomenological model is shown to have an excellent agreement with the experimental data and with the results obtained by the polarization tracking Monte Carlo model, developed in house. By analogy to diffusing-wave spectroscopy we call this approach diffusing-wave polarimetry, and illustrate its utility in probing cancerous and non-cancerous tissue samplesin vitro for diagnostic purposes.

AB - We exploit the directional awareness of circularly and/or elliptically polarized light propagating within media which exhibit high numbers of scattering events. By tracking the Stokes vector of the detected light on the Poincaŕe sphere, we demonstrate its applicability for characterization of anisotropy of scattering. A phenomenological model is shown to have an excellent agreement with the experimental data and with the results obtained by the polarization tracking Monte Carlo model, developed in house. By analogy to diffusing-wave spectroscopy we call this approach diffusing-wave polarimetry, and illustrate its utility in probing cancerous and non-cancerous tissue samplesin vitro for diagnostic purposes.

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KW - Circular polarization

KW - Helicity

KW - Monte Carlo

KW - Optical biopsy

KW - Poincaré sphere

KW - Polarimetry

KW - Stokes vector

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