DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

Susan J. Broughton, Cathy Slack, Nazif Alic, Athanasios Metaxakis, Timothy M. Bass, Yasmine Driege, Linda Partridge

Research output: Contribution to journalArticle

Abstract

Dietary restriction extends lifespan in diverse organisms, but the gene regulatory mechanisms and tissues mediating the increased survival are still unclear. Studies in worms and flies have revealed a number of candidate mechanisms, including the target of rapamycin and insulin/IGF-like signalling (IIS) pathways and suggested a specific role for the nervous system in mediating the response. A pair of sensory neurons in Caenorhabditis elegans has been found to specifically mediate DR lifespan extension, but a neuronal focus in the Drosophila nervous system has not yet been identified. We have previously shown that reducing IIS via the partial ablation of median neurosecretory cells in the Drosophila adult brain, which produce three of the seven fly insulin-like peptides, extends lifespan. Here, we show that these cells are required to mediate the response of lifespan to full feeding in a yeast dilution DR regime and that they appear to do so by mechanisms that involve both altered IIS and other endocrine effects. We also present evidence of an interaction between these mNSCs, nutrition and sleep, further emphasising the functional homology between the DILP-producing neurosecretory cells in the Drosophila brain and the hypothalamus of mammals in their roles as integration sites of many inputs for the control of lifespan and behaviour.

LanguageEnglish
Pages336-346
Number of pages11
JournalAging Cell
Volume9
Issue number3
Early online date12 Feb 2010
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Drosophila
Insulin
Brain
Diptera
Nervous System
Behavior Control
Caenorhabditis elegans
Sensory Receptor Cells
Sirolimus
Regulator Genes
Hypothalamus
Mammals
Sleep
Yeasts
Peptides

Bibliographical note

Corrected by: Corrigendum, Vol. 9, Issue 5, 930, Version of Record online: 16 SEP 2010

Keywords

  • Aging
  • Dietary restriction
  • Drosophila
  • Insulinlike peptide

Cite this

Broughton, Susan J. ; Slack, Cathy ; Alic, Nazif ; Metaxakis, Athanasios ; Bass, Timothy M. ; Driege, Yasmine ; Partridge, Linda. / DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. In: Aging Cell. 2010 ; Vol. 9, No. 3. pp. 336-346.
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DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. / Broughton, Susan J.; Slack, Cathy; Alic, Nazif; Metaxakis, Athanasios; Bass, Timothy M.; Driege, Yasmine; Partridge, Linda.

In: Aging Cell, Vol. 9, No. 3, 06.2010, p. 336-346.

Research output: Contribution to journalArticle

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AU - Bass, Timothy M.

AU - Driege, Yasmine

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