Direct laser-induced singlet oxygen in biological systems: application from in vitro              to in vivo

Viktor Dremin; Oxana Semyachkina-Glushkovskaya; Edik Rafailov

doi:10.1109/JSTQE.2023.3246587

Direct laser-induced singlet oxygen in biological systems: application from in vitro to in vivo

Viktor Dremin
, Oxana Semyachkina-Glushkovskaya
, Edik Rafailov

Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia
R&D Center of Biomedical Photonics, Orel State University, Orel, Oryol Oblast, Russia
College of Engineering and Physical Sciences, Aston University, Birmingham, U.K.

Research output: Contribution to journal › Review article › peer-review

13 Citations (SciVal)

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Abstract

In recent years, there has been increasing interest in the singlet form of oxygen as a regulator of the physiological functions of cells. The use of photosensitisers is a classical mechanism for the excitation of the main triplet form of oxygen and the generation of its singlet form. At the same time, it has been shown that there is a possibility of direct optical excitation of the main oxygen form into the singlet state by light at certain wavelengths. This review article aims to combine recent accumulated experience in the field of direct optical generation of singlet oxygen. We focus on works on the application of a 1267 nm wavelength, which is the most frequently used and well-studied in this area. In this review, we consider the use of laser-induced singlet oxygen in various biomedical applications both at the cellular level and at the level of whole organisms. This review presents the latest results on the use of singlet oxygen for therapeutic effects on cancer cells, as well as for photostimulation of neurons and the vascular and lymphatic systems.

Original language	English
Article number	7200911
Number of pages	11
Journal	IEEE Journal of Selected Topics in Quantum Electronics
Volume	29
Issue number	4
Early online date	20 Feb 2023
DOIs	https://doi.org/10.1109/JSTQE.2023.3246587
Publication status	Published - 1 Jul 2023

Bibliographical note

This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

singlet oxygen
direct optical generation
cancer
cardiovascular system
ATP production
photostimulation

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Direct_laser-induced_singlet_oxygen_in_biological_systems_application_from_in_vitro_to_in_vivo
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Cite this

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abstract = "In recent years, there has been increasing interest in the singlet form of oxygen as a regulator of the physiological functions of cells. The use of photosensitisers is a classical mechanism for the excitation of the main triplet form of oxygen and the generation of its singlet form. At the same time, it has been shown that there is a possibility of direct optical excitation of the main oxygen form into the singlet state by light at certain wavelengths. This review article aims to combine recent accumulated experience in the field of direct optical generation of singlet oxygen. We focus on works on the application of a 1267 nm wavelength, which is the most frequently used and well-studied in this area. In this review, we consider the use of laser-induced singlet oxygen in various biomedical applications both at the cellular level and at the level of whole organisms. This review presents the latest results on the use of singlet oxygen for therapeutic effects on cancer cells, as well as for photostimulation of neurons and the vascular and lymphatic systems.",

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AB - In recent years, there has been increasing interest in the singlet form of oxygen as a regulator of the physiological functions of cells. The use of photosensitisers is a classical mechanism for the excitation of the main triplet form of oxygen and the generation of its singlet form. At the same time, it has been shown that there is a possibility of direct optical excitation of the main oxygen form into the singlet state by light at certain wavelengths. This review article aims to combine recent accumulated experience in the field of direct optical generation of singlet oxygen. We focus on works on the application of a 1267 nm wavelength, which is the most frequently used and well-studied in this area. In this review, we consider the use of laser-induced singlet oxygen in various biomedical applications both at the cellular level and at the level of whole organisms. This review presents the latest results on the use of singlet oxygen for therapeutic effects on cancer cells, as well as for photostimulation of neurons and the vascular and lymphatic systems.

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