Discovery of a potent phenolic N1-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria

Daniel L. Rathbone; Katy J. Parker; Michael D. Coleman; Peter A. Lambert; David C. Billington

doi:10.1016/j.bmcl.2005.11.005

Discovery of a potent phenolic N¹-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria

Daniel L. Rathbone^*, Katy J. Parker, Michael D. Coleman, Peter A. Lambert, David C. Billington

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

As part of a study into antimycobacterial compounds a set of phenolic N¹-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. © 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	879-883
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2005.11.005
Publication status	Published - 15 Feb 2006

Keywords

antimicrobial
carboxamidrazone
MRSA

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10.1016/j.bmcl.2005.11.005

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title = "Discovery of a potent phenolic N1-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria",

abstract = "As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",

keywords = "antimicrobial, carboxamidrazone, MRSA",

author = "Rathbone, {Daniel L.} and Parker, {Katy J.} and Coleman, {Michael D.} and Lambert, {Peter A.} and Billington, {David C.}",

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AU - Rathbone, Daniel L.

AU - Parker, Katy J.

AU - Coleman, Michael D.

AU - Lambert, Peter A.

AU - Billington, David C.

PY - 2006/2/15

Y1 - 2006/2/15

N2 - As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. © 2005 Elsevier Ltd. All rights reserved.

AB - As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. © 2005 Elsevier Ltd. All rights reserved.

KW - antimicrobial

KW - carboxamidrazone

KW - MRSA

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U2 - 10.1016/j.bmcl.2005.11.005

DO - 10.1016/j.bmcl.2005.11.005

M3 - Article

C2 - 16298528

SN - 0960-894X

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SP - 879

EP - 883

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Discovery of a potent phenolic N¹-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria

Abstract

Keywords

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