Discovery of a potent phenolic N1-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria

Daniel L. Rathbone*, Katy J. Parker, Michael D. Coleman, Peter A. Lambert, David C. Billington

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. © 2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)879-883
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number4
DOIs
Publication statusPublished - 15 Feb 2006

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Gram-Positive Bacteria
Bacteria
Pharmaceutical Preparations

Keywords

  • antimicrobial
  • carboxamidrazone
  • MRSA

Cite this

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abstract = "As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. {\circledC} 2005 Elsevier Ltd. All rights reserved.",
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author = "Rathbone, {Daniel L.} and Parker, {Katy J.} and Coleman, {Michael D.} and Lambert, {Peter A.} and Billington, {David C.}",
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AU - Rathbone, Daniel L.

AU - Parker, Katy J.

AU - Coleman, Michael D.

AU - Lambert, Peter A.

AU - Billington, David C.

PY - 2006/2/15

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AB - As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. © 2005 Elsevier Ltd. All rights reserved.

KW - antimicrobial

KW - carboxamidrazone

KW - MRSA

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