Discovery of a potent phenolic N1-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria

Daniel L. Rathbone*, Katy J. Parker, Michael D. Coleman, Peter A. Lambert, David C. Billington

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria. © 2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)879-883
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
Publication statusPublished - 15 Feb 2006


  • antimicrobial
  • carboxamidrazone
  • MRSA


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