Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior

Lisa A. Pan, Silvia C. Batezati-Alves, Jorge R.C. Almeida, Annamaria Segreti, Dalila Akkal, Stefanie Hassel, Sara Lakdawala, David A. Brent, Mary L. Phillips

Research output: Contribution to journalArticle

Abstract

Objectives - Impaired attentional control and behavioral control are implicated in adult suicidal behavior. Little is known about the functional integrity of neural circuitry supporting these processes in suicidal behavior in adolescence.
Method - Functional magnetic resonance imaging was used in 15 adolescent suicide attempters with a history of major depressive disorder (ATTs), 15 adolescents with a history of depressive disorder but no suicide attempt (NATs), and 14 healthy controls (HCs) during the performance of a well-validated go-no-go response inhibition and motor control task that measures attentional and behavioral control and has been shown to activate prefrontal, anterior cingulate, and parietal cortical circuitries. Questionnaires assessed symptoms and standardized interviews characterized suicide attempts.
Results - A 3 group by 2 condition (go-no-go response inhibition versus go motor control blocks) block-design whole-brain analysis (p < .05, corrected) showed that NATs showed greater activity than ATTs in the right anterior cingulate gyrus (p = .008), and that NATs, but not ATTs, showed significantly greater activity than HCs in the left insula (p = .004) to go-no-go response inhibition blocks.
Conclusions - Although ATTs did not show differential patterns of neural activity from HCs during the go-no-go response inhibition blocks, ATTs and NATs showed differential activation of the right anterior cingulate gyrus during response inhibition. These findings indicate that suicide attempts during adolescence are not associated with abnormal activity in response inhibition neural circuitry. The differential patterns of activity in response inhibition neural circuitry in ATTs and NATs, however, suggest different neural mechanisms for suicide attempt versus major depressive disorder in general in adolescence that should be a focus of further study.
Original languageEnglish
Pages (from-to)602-611.e3
Number of pages10
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume50
Issue number6
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Suicide
Gyrus Cinguli
Neural Inhibition
Major Depressive Disorder
Depressive Disorder
Magnetic Resonance Imaging
N-acetyltalosaminuronic acid
Inhibition (Psychology)
Interviews
Brain

Keywords

  • magnetic resonance imaging
  • attempted suicide
  • humans
  • major depressive disorder
  • nerve net
  • suicidal ideation
  • three-dimensional imaging
  • mesencephalon
  • oxygen consumption
  • gyrus cinguli
  • visual pattern recognition
  • temporal lobe
  • adolescent
  • antidepressive agents
  • male
  • inhibition (psychology)
  • reference values
  • brain
  • prefrontal cortex
  • cerebral dominance
  • antipsychotic agents
  • parietal lobe
  • frontal lobe
  • cerebral cortex
  • brain mapping
  • psychomotor performance
  • attention
  • computer-assisted image processing
  • female
  • anticonvulsants
  • suicide
  • response inhibition
  • cingulate

Cite this

Pan, Lisa A. ; Batezati-Alves, Silvia C. ; Almeida, Jorge R.C. ; Segreti, Annamaria ; Akkal, Dalila ; Hassel, Stefanie ; Lakdawala, Sara ; Brent, David A. ; Phillips, Mary L. / Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2011 ; Vol. 50, No. 6. pp. 602-611.e3.
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abstract = "Objectives - Impaired attentional control and behavioral control are implicated in adult suicidal behavior. Little is known about the functional integrity of neural circuitry supporting these processes in suicidal behavior in adolescence.Method - Functional magnetic resonance imaging was used in 15 adolescent suicide attempters with a history of major depressive disorder (ATTs), 15 adolescents with a history of depressive disorder but no suicide attempt (NATs), and 14 healthy controls (HCs) during the performance of a well-validated go-no-go response inhibition and motor control task that measures attentional and behavioral control and has been shown to activate prefrontal, anterior cingulate, and parietal cortical circuitries. Questionnaires assessed symptoms and standardized interviews characterized suicide attempts. Results - A 3 group by 2 condition (go-no-go response inhibition versus go motor control blocks) block-design whole-brain analysis (p < .05, corrected) showed that NATs showed greater activity than ATTs in the right anterior cingulate gyrus (p = .008), and that NATs, but not ATTs, showed significantly greater activity than HCs in the left insula (p = .004) to go-no-go response inhibition blocks. Conclusions - Although ATTs did not show differential patterns of neural activity from HCs during the go-no-go response inhibition blocks, ATTs and NATs showed differential activation of the right anterior cingulate gyrus during response inhibition. These findings indicate that suicide attempts during adolescence are not associated with abnormal activity in response inhibition neural circuitry. The differential patterns of activity in response inhibition neural circuitry in ATTs and NATs, however, suggest different neural mechanisms for suicide attempt versus major depressive disorder in general in adolescence that should be a focus of further study.",
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author = "Pan, {Lisa A.} and Batezati-Alves, {Silvia C.} and Almeida, {Jorge R.C.} and Annamaria Segreti and Dalila Akkal and Stefanie Hassel and Sara Lakdawala and Brent, {David A.} and Phillips, {Mary L.}",
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Pan, LA, Batezati-Alves, SC, Almeida, JRC, Segreti, A, Akkal, D, Hassel, S, Lakdawala, S, Brent, DA & Phillips, ML 2011, 'Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 50, no. 6, pp. 602-611.e3. https://doi.org/10.1016/j.jaac.2011.03.018

Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior. / Pan, Lisa A.; Batezati-Alves, Silvia C.; Almeida, Jorge R.C.; Segreti, Annamaria; Akkal, Dalila; Hassel, Stefanie; Lakdawala, Sara; Brent, David A.; Phillips, Mary L.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 50, No. 6, 06.2011, p. 602-611.e3.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior

AU - Pan, Lisa A.

AU - Batezati-Alves, Silvia C.

AU - Almeida, Jorge R.C.

AU - Segreti, Annamaria

AU - Akkal, Dalila

AU - Hassel, Stefanie

AU - Lakdawala, Sara

AU - Brent, David A.

AU - Phillips, Mary L.

PY - 2011/6

Y1 - 2011/6

N2 - Objectives - Impaired attentional control and behavioral control are implicated in adult suicidal behavior. Little is known about the functional integrity of neural circuitry supporting these processes in suicidal behavior in adolescence.Method - Functional magnetic resonance imaging was used in 15 adolescent suicide attempters with a history of major depressive disorder (ATTs), 15 adolescents with a history of depressive disorder but no suicide attempt (NATs), and 14 healthy controls (HCs) during the performance of a well-validated go-no-go response inhibition and motor control task that measures attentional and behavioral control and has been shown to activate prefrontal, anterior cingulate, and parietal cortical circuitries. Questionnaires assessed symptoms and standardized interviews characterized suicide attempts. Results - A 3 group by 2 condition (go-no-go response inhibition versus go motor control blocks) block-design whole-brain analysis (p < .05, corrected) showed that NATs showed greater activity than ATTs in the right anterior cingulate gyrus (p = .008), and that NATs, but not ATTs, showed significantly greater activity than HCs in the left insula (p = .004) to go-no-go response inhibition blocks. Conclusions - Although ATTs did not show differential patterns of neural activity from HCs during the go-no-go response inhibition blocks, ATTs and NATs showed differential activation of the right anterior cingulate gyrus during response inhibition. These findings indicate that suicide attempts during adolescence are not associated with abnormal activity in response inhibition neural circuitry. The differential patterns of activity in response inhibition neural circuitry in ATTs and NATs, however, suggest different neural mechanisms for suicide attempt versus major depressive disorder in general in adolescence that should be a focus of further study.

AB - Objectives - Impaired attentional control and behavioral control are implicated in adult suicidal behavior. Little is known about the functional integrity of neural circuitry supporting these processes in suicidal behavior in adolescence.Method - Functional magnetic resonance imaging was used in 15 adolescent suicide attempters with a history of major depressive disorder (ATTs), 15 adolescents with a history of depressive disorder but no suicide attempt (NATs), and 14 healthy controls (HCs) during the performance of a well-validated go-no-go response inhibition and motor control task that measures attentional and behavioral control and has been shown to activate prefrontal, anterior cingulate, and parietal cortical circuitries. Questionnaires assessed symptoms and standardized interviews characterized suicide attempts. Results - A 3 group by 2 condition (go-no-go response inhibition versus go motor control blocks) block-design whole-brain analysis (p < .05, corrected) showed that NATs showed greater activity than ATTs in the right anterior cingulate gyrus (p = .008), and that NATs, but not ATTs, showed significantly greater activity than HCs in the left insula (p = .004) to go-no-go response inhibition blocks. Conclusions - Although ATTs did not show differential patterns of neural activity from HCs during the go-no-go response inhibition blocks, ATTs and NATs showed differential activation of the right anterior cingulate gyrus during response inhibition. These findings indicate that suicide attempts during adolescence are not associated with abnormal activity in response inhibition neural circuitry. The differential patterns of activity in response inhibition neural circuitry in ATTs and NATs, however, suggest different neural mechanisms for suicide attempt versus major depressive disorder in general in adolescence that should be a focus of further study.

KW - magnetic resonance imaging

KW - attempted suicide

KW - humans

KW - major depressive disorder

KW - nerve net

KW - suicidal ideation

KW - three-dimensional imaging

KW - mesencephalon

KW - oxygen consumption

KW - gyrus cinguli

KW - visual pattern recognition

KW - temporal lobe

KW - adolescent

KW - antidepressive agents

KW - male

KW - inhibition (psychology)

KW - reference values

KW - brain

KW - prefrontal cortex

KW - cerebral dominance

KW - antipsychotic agents

KW - parietal lobe

KW - frontal lobe

KW - cerebral cortex

KW - brain mapping

KW - psychomotor performance

KW - attention

KW - computer-assisted image processing

KW - female

KW - anticonvulsants

KW - suicide

KW - response inhibition

KW - cingulate

U2 - 10.1016/j.jaac.2011.03.018

DO - 10.1016/j.jaac.2011.03.018

M3 - Article

C2 - 21621144

VL - 50

SP - 602-611.e3

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 6

ER -