Distribution of A4 protein and neurofibrillary change in the hippocampus in Alzheimer's disease

Richard A. Armstrong, D. Myers, C.U.M. Smith

Research output: Contribution to conferencePoster

Abstract

The principal components of classical senile plaques (SP) in Alzheimer's disease (AD) appear to be A4/beta protein and paired helical filaments (PHF). A4 deposits may evolve into classical SP in brain regions vulnerable to the formation of PHF. We have investigated the diatribution of A4 deposits using an immunostain and the neurofibrillary change using the Gallyas stain in various regions of the hippocampus. This region is particularly affected in AD and also has relatively restricted inputs and outputs. In 6 patients we found a significant preponderance of A4 deposits in the adjacent parahippocampal gyrus (PHG) compared with all regions of the hippocampus. However, plaque-like clusters of PHF (Gallyas plaques) were more abundant in the subiculum while neurofibrillary tangles (NFT) were more abundant in the subiculum and region CA1 compared with the PHG and other hippocampal regions. Hence, A4 deposits appear to be concentrated in the region providing a major input into the hippocampus while the neurofibrillary changes are characteristic of the major output areas (subiculum and CA1). Hence, the data suggest that A4 formation and the neurofibrillary changes may occur in regions of the hippocampus that are connected anatomically.
Original languageEnglish
Publication statusPublished - 1991
Event8th International Meeting of the Brain Research Association -
Duration: 1 Jan 19921 Jan 1992

Conference

Conference8th International Meeting of the Brain Research Association
Period1/01/921/01/92

Bibliographical note

Abstract appearing in Euro. J. Neuro. Suppl. 4:P182.

Keywords

  • classical senile plaques
  • Alzheimer's disease
  • A4/beta protein
  • paired helical filaments
  • brain

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    Armstrong, R. A., Myers, D., & Smith, C. U. M. (1991). Distribution of A4 protein and neurofibrillary change in the hippocampus in Alzheimer's disease. Poster session presented at 8th International Meeting of the Brain Research Association, .