This paper presents vapor−liquid equilibrium (VLE) data for systems containing high-pressure CO2, an ionic liquid, and products of an enzymatic reaction between succinic anhydride and (R,S)-2-octanol in the presence of a lipase. VLE experiments were used to calculate partition coefficients of reaction products between the ionic liquid-rich phase and the CO2-rich phase. Experiments of extraction with CO2 from an ionic liquid of (S)-2-octanol in conditions similar to those of the postreaction mixture were also carried out. The extraction at 11 MPa and 35 °C allows one to recover completely the unreacted enantiomer of 2-octanol with very high enantiomeric excess (98.42%).
Bogel-Łukasik, R., Najdanovic-Visak, V., Barreiros, S., & Da Ponte, M. N. (2008). Distribution ratios of lipase-catalyzed reaction products in ionic liquid supercritical CO2 systems: Resolution of 2-octanol enantiomers. Industrial and Engineering Chemistry Research, 47(13), 4473-4480. https://doi.org/10.1021/ie0714100