Distribution ratios of lipase-catalyzed reaction products in ionic liquid supercritical CO2 systems: Resolution of 2-octanol enantiomers

R. Bogel-Łukasik, V. Najdanovic-Visak, S. Barreiros, M.N. Da Ponte

Research output: Contribution to journalArticle

Abstract

This paper presents vapor−liquid equilibrium (VLE) data for systems containing high-pressure CO2, an ionic liquid, and products of an enzymatic reaction between succinic anhydride and (R,S)-2-octanol in the presence of a lipase. VLE experiments were used to calculate partition coefficients of reaction products between the ionic liquid-rich phase and the CO2-rich phase. Experiments of extraction with CO2 from an ionic liquid of (S)-2-octanol in conditions similar to those of the postreaction mixture were also carried out. The extraction at 11 MPa and 35 °C allows one to recover completely the unreacted enantiomer of 2-octanol with very high enantiomeric excess (98.42%).
Original languageEnglish
Pages (from-to)4473-4480
JournalIndustrial and Engineering Chemistry Research
Volume47
Issue number13
DOIs
Publication statusPublished - 5 Jun 2008

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Ionic Liquids
Enantiomers
Lipases
Lipase
Reaction products
Ionic liquids
Experiments
2-octanol

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title = "Distribution ratios of lipase-catalyzed reaction products in ionic liquid supercritical CO2 systems: Resolution of 2-octanol enantiomers",
abstract = "This paper presents vapor−liquid equilibrium (VLE) data for systems containing high-pressure CO2, an ionic liquid, and products of an enzymatic reaction between succinic anhydride and (R,S)-2-octanol in the presence of a lipase. VLE experiments were used to calculate partition coefficients of reaction products between the ionic liquid-rich phase and the CO2-rich phase. Experiments of extraction with CO2 from an ionic liquid of (S)-2-octanol in conditions similar to those of the postreaction mixture were also carried out. The extraction at 11 MPa and 35 °C allows one to recover completely the unreacted enantiomer of 2-octanol with very high enantiomeric excess (98.42{\%}).",
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Distribution ratios of lipase-catalyzed reaction products in ionic liquid supercritical CO2 systems: Resolution of 2-octanol enantiomers. / Bogel-Łukasik, R.; Najdanovic-Visak, V.; Barreiros, S.; Da Ponte, M.N.

In: Industrial and Engineering Chemistry Research, Vol. 47, No. 13, 05.06.2008, p. 4473-4480.

Research output: Contribution to journalArticle

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T1 - Distribution ratios of lipase-catalyzed reaction products in ionic liquid supercritical CO2 systems: Resolution of 2-octanol enantiomers

AU - Bogel-Łukasik, R.

AU - Najdanovic-Visak, V.

AU - Barreiros, S.

AU - Da Ponte, M.N.

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AB - This paper presents vapor−liquid equilibrium (VLE) data for systems containing high-pressure CO2, an ionic liquid, and products of an enzymatic reaction between succinic anhydride and (R,S)-2-octanol in the presence of a lipase. VLE experiments were used to calculate partition coefficients of reaction products between the ionic liquid-rich phase and the CO2-rich phase. Experiments of extraction with CO2 from an ionic liquid of (S)-2-octanol in conditions similar to those of the postreaction mixture were also carried out. The extraction at 11 MPa and 35 °C allows one to recover completely the unreacted enantiomer of 2-octanol with very high enantiomeric excess (98.42%).

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