DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Mariaelena Repici; Flaviano Giorgini

doi:10.3390/jcm8091377

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Mariaelena Repici, Flaviano Giorgini

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Abstract

Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

Original language	English
Article number	1377
Journal	Journal of Clinical Medicine
Volume	8
Issue number	9
DOIs	https://doi.org/10.3390/jcm8091377
Publication status	Published - 3 Sept 2019

Bibliographical note

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Funding: Wellcome Trust WT-ISSF.

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DJ-1 in Parkinson’s DiseaseFinal published version, 465 KBLicence: CC BY 3.0

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title = "DJ-1 in Parkinson{\textquoteright}s Disease: Clinical Insights and Therapeutic Perspectives",

abstract = "Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson{\textquoteright}s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration. ",

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AU - Giorgini, Flaviano

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N2 - Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

AB - Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

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JO - Journal of Clinical Medicine

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ER -

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

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