DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Mariaelena Repici; Flaviano Giorgini

doi:10.3390/jcm8091377

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Mariaelena Repici
, Flaviano Giorgini

Research output: Contribution to journal › Review article › peer-review

163 Citations (SciVal)

88 Downloads (Pure)

Abstract

Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

Original language	English
Article number	1377
Journal	Journal of Clinical Medicine
Volume	8
Issue number	9
DOIs	https://doi.org/10.3390/jcm8091377
Publication status	Published - 3 Sept 2019

Bibliographical note

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Funding: Wellcome Trust WT-ISSF.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.3390/jcm8091377Licence: CC BY 3.0

DJ-1 in Parkinson’s DiseaseFinal published version, 465 KBLicence: CC BY 3.0

Cite this

@article{25f371e504674677abadd8caccb63b78,

title = "DJ-1 in Parkinson{\textquoteright}s Disease: Clinical Insights and Therapeutic Perspectives",

abstract = "Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson{\textquoteright}s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration. ",

author = "Mariaelena Repici and Flaviano Giorgini",

note = "{\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Funding: Wellcome Trust WT-ISSF.",

year = "2019",

month = sep,

day = "3",

doi = "10.3390/jcm8091377",

language = "English",

volume = "8",

journal = "Journal of Clinical Medicine ",

publisher = "MDPI AG",

number = "9",

}

TY - JOUR

T1 - DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

AU - Repici, Mariaelena

AU - Giorgini, Flaviano

N1 - © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Funding: Wellcome Trust WT-ISSF.

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

AB - Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

UR - https://www.mdpi.com/2077-0383/8/9/1377

U2 - 10.3390/jcm8091377

DO - 10.3390/jcm8091377

M3 - Review article

VL - 8

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 9

M1 - 1377

ER -

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this