Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?

M. Sakel, A. Boukouvalas, R. Buono, M. Moten, F. Mirza, W.-Y. Chan, I. Maidment, J. Cross, T.O. Smith, P.K. Myint, C. Fox

Research output: Contribution to journalArticle

Abstract

Primary objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury.

Research design: A retrospective case note review assessed total rehabilitation unit admission.

Methods and procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a UK university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge.

Main outcomes and results: A positive change was reported in ACB results in a positive change in NPDS, with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation = −6.64; SE = 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR = 9.65; 95% CI = 1.36–68.64) and FIM-FAM Total scores (OR = 0.03; 95% CI = 0.002–0.35).

Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.
Original languageEnglish
Pages (from-to)1426-1430
Number of pages5
JournalBrain Injury
Volume29
Issue number12
Early online date5 Aug 2015
DOIs
Publication statusPublished - 2015

Fingerprint

Cholinergic Antagonists
Length of Stay
Outcome Assessment (Health Care)
Rehabilitation
Pharmaceutical Preparations
Spinal Injuries
Drugs
Burden
Length
Spinal Cord Injuries
Brain Injuries
Research Design
Brain

Keywords

  • adverse event
  • Anticholingeric
  • function
  • length of stay
  • rehabilitation unit
  • spinal cord
  • traumatic brain injury

Cite this

Sakel, M. ; Boukouvalas, A. ; Buono, R. ; Moten, M. ; Mirza, F. ; Chan, W.-Y. ; Maidment, I. ; Cross, J. ; Smith, T.O. ; Myint, P.K. ; Fox, C. / Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?. In: Brain Injury. 2015 ; Vol. 29, No. 12. pp. 1426-1430.
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abstract = "Primary objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury.Research design: A retrospective case note review assessed total rehabilitation unit admission.Methods and procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a UK university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge.Main outcomes and results: A positive change was reported in ACB results in a positive change in NPDS, with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation = −6.64; SE = 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR = 9.65; 95{\%} CI = 1.36–68.64) and FIM-FAM Total scores (OR = 0.03; 95{\%} CI = 0.002–0.35).Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.",
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Sakel, M, Boukouvalas, A, Buono, R, Moten, M, Mirza, F, Chan, W-Y, Maidment, I, Cross, J, Smith, TO, Myint, PK & Fox, C 2015, 'Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?', Brain Injury, vol. 29, no. 12, pp. 1426-1430. https://doi.org/10.3109/02699052.2015.1060358

Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay? / Sakel, M.; Boukouvalas, A.; Buono, R.; Moten, M.; Mirza, F.; Chan, W.-Y.; Maidment, I.; Cross, J.; Smith, T.O.; Myint, P.K.; Fox, C.

In: Brain Injury, Vol. 29, No. 12, 2015, p. 1426-1430.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?

AU - Sakel, M.

AU - Boukouvalas, A.

AU - Buono, R.

AU - Moten, M.

AU - Mirza, F.

AU - Chan, W.-Y.

AU - Maidment, I.

AU - Cross, J.

AU - Smith, T.O.

AU - Myint, P.K.

AU - Fox, C.

PY - 2015

Y1 - 2015

N2 - Primary objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury.Research design: A retrospective case note review assessed total rehabilitation unit admission.Methods and procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a UK university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge.Main outcomes and results: A positive change was reported in ACB results in a positive change in NPDS, with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation = −6.64; SE = 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR = 9.65; 95% CI = 1.36–68.64) and FIM-FAM Total scores (OR = 0.03; 95% CI = 0.002–0.35).Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.

AB - Primary objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury.Research design: A retrospective case note review assessed total rehabilitation unit admission.Methods and procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a UK university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge.Main outcomes and results: A positive change was reported in ACB results in a positive change in NPDS, with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation = −6.64; SE = 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR = 9.65; 95% CI = 1.36–68.64) and FIM-FAM Total scores (OR = 0.03; 95% CI = 0.002–0.35).Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.

KW - adverse event

KW - Anticholingeric

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