Abstract
Eicosapentaenoic acid (EPA) has been shown to attenuate muscle atrophy in cancer, starvation and hyperthermia by downregulating the increased expression of the ubiquitin-proteasome proteolytic pathway leading to a reduction in protein degradation. In the current study EPA (0.5 g/kg) administered to septic mice completely attenuated the increased protein degradation in skeletal muscle by preventing the increase in both gene expression and protein concentration of the alpha- and beta-subunits of the 20S proteasome, as well as functional activity of the proteasome, as measured by the 'chymotrypsin-like' enzyme activity. These results suggest that muscle protein catabolism in sepsis is mediated by the same intracellular signalling pathways as found in other catabolic conditions.
Original language | English |
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Pages (from-to) | 238-240 |
Number of pages | 3 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 375 |
Issue number | 2 |
Early online date | 12 Aug 2008 |
DOIs | |
Publication status | Published - 17 Oct 2008 |
Keywords
- sepsis
- muscle atrophy
- EPA
- ubiquitin-proteasome proteolysis