Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Clifford Bailey, S Del Prato, D Eddy, B Zinman

Research output: Contribution to journalArticle

Abstract

In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression. © Blackwell Publishing Ltd, 2005.

Original languageEnglish
Pages (from-to)1309-1316
Number of pages8
JournalInternational Journal of Clinical Practice
Volume59
Issue number11
Early online date12 Oct 2005
DOIs
Publication statusPublished - Nov 2005

Keywords

  • archimedes model
  • combination therapy
  • early intervention
  • glycaemic control
  • type 2 diabetes

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