Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia

Matthew D. Barber, Kenneth C.H. Fearon, Michael J. Tisdale, Donald C. McMillan, James A. Ross

Research output: Contribution to journalArticle

Abstract

Weight loss in advanced cancer patients is refractory to conventional nutritional support. This may be due to metabolic changes mediated by proinflammatory cytokines, hormones, and tumor-derived products. We previously showed that a nutritional supplement enriched with fish oil will reverse weight loss in patients with pancreatic cancer cachexia. The present study examines the effect of this supplement on a number of mediators thought to play a role in cancer cachexia. Twenty weight-losing patients with pancreatic cancer were asked to consume a nutritional supplement providing 600 kcal and 2 g of eicosapentaenoic acid per day. At baseline and after 3 wk, patients were weighed and samples were collected to measure serum concentrations of interleukin (IL)-6 and its soluble receptor tumor necrosis factor receptors I and II, cortisol, insulin, and leptin, peripheral blood mononuclear cell production of IL-1 beta, IL-6, and tumor necrosis factor, and urinary excretion of proteolysis inducing factor. After 3 wk of consumption of the fish oil-enriched nutritional supplement, there was a significant fall in production of IL-6 (from median 16.5 to 13.7 ng/ml, P = 0.015), a rise in serum insulin concentration (from 3.3 to 5.0 mU/l, P = 0.0064), a fall in the cortisol-to-insulin ratio (P = 0.0084), and a fall in the proportion of patients excreting proteolysis inducing factor (from 88% to 40%, P = 0.008). These changes occurred in association with weight gain (median 1 kg, P = 0.024). Various mediators of catabolism in cachexia are modulated by administration of a fish oil-enriched nutritional supplement in pancreatic cancer patients. This may account for the reversal of weight loss in patients consuming this supplement.
Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalNutrition and Cancer
Volume40
Issue number2
DOIs
Publication statusPublished - May 2001

Fingerprint

Cachexia
Fish Oils
Pancreatic Neoplasms
Weight Loss
Interleukin-6
Insulin
Proteolysis
Hydrocortisone
Neoplasms
Eicosapentaenoic Acid
Nutritional Support
Tumor Necrosis Factor Receptors
Leptin
Serum
Interleukin-1beta
Weight Gain
Blood Cells
Tumor Necrosis Factor-alpha
Hormones
Cytokines

Keywords

  • fish oil
  • food supplement
  • pancreatic cancer
  • cachexia

Cite this

Barber, Matthew D. ; Fearon, Kenneth C.H. ; Tisdale, Michael J. ; McMillan, Donald C. ; Ross, James A. / Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. In: Nutrition and Cancer. 2001 ; Vol. 40, No. 2. pp. 118-124.
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Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. / Barber, Matthew D.; Fearon, Kenneth C.H.; Tisdale, Michael J.; McMillan, Donald C.; Ross, James A.

In: Nutrition and Cancer, Vol. 40, No. 2, 05.2001, p. 118-124.

Research output: Contribution to journalArticle

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