Effect of catechol derivatives on cell growth and lipoxygenase activity

Julie Simpson; Rebecca Forrester; Michael J. Tisdale; David C. Billington; Daniel L. Rathbone

doi:10.1016/S0960-894X(03)00528-6

Effect of catechol derivatives on cell growth and lipoxygenase activity

Julie Simpson
, Rebecca Forrester
, Michael J. Tisdale
, David C. Billington
, Daniel L. Rathbone^*

^*Corresponding author for this work

Aston University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC ₅₀10 ^-6-10 ^-7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC ₅₀ ∼1 μM). © 2003 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2435-2439
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(03)00528-6
Publication status	Published - 4 Aug 2003

Keywords

salicylic acid
lipoxygenase inhibitors
phenolic dihydroxy moiety
murine colonic tumour cells
inhibitors
catechols

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10.1016/S0960-894X(03)00528-6

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title = "Effect of catechol derivatives on cell growth and lipoxygenase activity",

abstract = "Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC 5010 -6-10 -7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC 50 ∼1 μM). {\textcopyright} 2003 Elsevier Ltd. All rights reserved.",

keywords = "salicylic acid, lipoxygenase inhibitors, phenolic dihydroxy moiety, murine colonic tumour cells, inhibitors, catechols",

author = "Julie Simpson and Rebecca Forrester and Tisdale, \{Michael J.\} and Billington, \{David C.\} and Rathbone, \{Daniel L.\}",

year = "2003",

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doi = "10.1016/S0960-894X(03)00528-6",

language = "English",

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TY - JOUR

T1 - Effect of catechol derivatives on cell growth and lipoxygenase activity

AU - Simpson, Julie

AU - Forrester, Rebecca

AU - Tisdale, Michael J.

AU - Billington, David C.

AU - Rathbone, Daniel L.

PY - 2003/8/4

Y1 - 2003/8/4

N2 - Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC 5010 -6-10 -7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC 50 ∼1 μM). © 2003 Elsevier Ltd. All rights reserved.

AB - Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC 5010 -6-10 -7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC 50 ∼1 μM). © 2003 Elsevier Ltd. All rights reserved.

KW - salicylic acid

KW - lipoxygenase inhibitors

KW - phenolic dihydroxy moiety

KW - murine colonic tumour cells

KW - inhibitors

KW - catechols

UR - https://www.scopus.com/pages/publications/0037972031

U2 - 10.1016/S0960-894X(03)00528-6

DO - 10.1016/S0960-894X(03)00528-6

M3 - Article

C2 - 12852938

SN - 0960-894X

VL - 13

SP - 2435

EP - 2439

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Effect of catechol derivatives on cell growth and lipoxygenase activity

Abstract

Keywords

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