Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: A randomized controlled trial

Hannah E. Bartlett*, Frank Eperjesi

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the study is to determine the effect of lutein combined with vitamin and mineral supplementation on contrast sensitivity in people with age-related macular disease (ARMD). Design: A prospective, 9-month, double-masked randomized controlled trial. Setting: Aston University, Birmingham, UK and a UK optometric clinical practice. Subjects: Age-related maculopathy (ARM) and atrophic age-related macular degeneration (AMD) participants were randomized (using a random number generator) to either placebo (n = 10) or active (n=15) groups. Three of the placebo group and two of the active group dropped out. Interventions: The active group supplemented daily with 6 mg lutein combined with vitamins and minerals. The outcome measure was contrast sensitivity (CS) measured using the Pelli-Robson chart, for which the study had 80% power at the 5% significance level to detect a change of 0.3log units. Results: The CS score increased by 0.07 ± 0.07 and decreased by 0.02 ± 0.18 log units for the placebo and active groups, respectively. The difference between these values is not statistically significant (z = 0.903, P = 0.376). Conclusion: The results suggest that 6 mg of lutein supplementation in combination with other antioxidants is not beneficial for this group. Further work is required to establish optimum dosage levels.

Original languageEnglish
Pages (from-to)1121-1127
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Volume61
Issue number9
DOIs
Publication statusPublished - Sep 2007

Bibliographical note

Copyright of the Nature Publishing Group

Keywords

  • age-related macular disease
  • lutein
  • randomized controlled trial
  • nutrition
  • antioxidants

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