Effect of type-2 diabetes on surface lipids and biophysical properties in lipoprotein populations

Ana Reis; Ana Rita D Araújo; Irundika Hk Dias; Bruno Antonny; Antonio Perez; Jose Luis Sánchez-Quesada; Victor de Freitas

doi:10.1016/j.abb.2026.110780

Effect of type-2 diabetes on surface lipids and biophysical properties in lipoprotein populations

Ana Reis
, Ana Rita D Araújo
, Irundika Hk Dias
, Bruno Antonny
, Antonio Perez
, Jose Luis Sánchez-Quesada
, Victor de Freitas

Universidade do Porto
Université Côte d'Azur
Hospital de La Santa Creu I Sant Pau
CIBER of Diabetes and Metabolic Diseases (CIBERDEM), 28029, Madrid, Spain; Endocrinology Department, Hospital de la Santa Creu i Sant Pau, Sant Antoni Ma Claret, 167, Barcelona, Spain.

Research output: Contribution to journal › Article › peer-review

Abstract

Surface lipids in lipoproteins interact with proteins and receptors at the surface of cell membranes, mediating lipoprotein-cell signaling and trafficking events. Despite this, little is known about lipoproteins' surface lipid composition and any changes introduced by type-2 diabetes mellitus (T2DM). Herein, we investigate the surface lipid composition in purified VLDL, LDL and HDL populations isolated from patients with poor (PC, HbA1c>8.5%) and good glycemic control (GC, HbA1c

Original language	English
Article number	110780
Number of pages	7
Journal	Archives of Biochemistry and Biophysics
Volume	779
Early online date	2 Mar 2026
DOIs	https://doi.org/10.1016/j.abb.2026.110780
Publication status	E-pub ahead of print - 2 Mar 2026

Bibliographical note

Funding

I.H.K. Dias acknowledges funding from Diabetes UK (grant number 22/0006432).

Keywords

Anisotropy
Mass spectrometry
Glucosyl-ceramides
Zeta-potential
HPTLC
Cholesterol sulfate

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10.1016/j.abb.2026.110780Licence: CC BY 4.0

Effect of type-2 diabetes on surface lipids and biophysical properties in lipoprotein populations
© 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Final published version, 2.16 MBLicence: CC BY 4.0

Cite this

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abstract = "Surface lipids in lipoproteins interact with proteins and receptors at the surface of cell membranes, mediating lipoprotein-cell signaling and trafficking events. Despite this, little is known about lipoproteins' surface lipid composition and any changes introduced by type-2 diabetes mellitus (T2DM). Herein, we investigate the surface lipid composition in purified VLDL, LDL and HDL populations isolated from patients with poor (PC, HbA1c>8.5\%) and good glycemic control (GC, HbA1c",

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AU - Perez, Antonio

AU - Sánchez-Quesada, Jose Luis

AU - de Freitas, Victor

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AB - Surface lipids in lipoproteins interact with proteins and receptors at the surface of cell membranes, mediating lipoprotein-cell signaling and trafficking events. Despite this, little is known about lipoproteins' surface lipid composition and any changes introduced by type-2 diabetes mellitus (T2DM). Herein, we investigate the surface lipid composition in purified VLDL, LDL and HDL populations isolated from patients with poor (PC, HbA1c>8.5%) and good glycemic control (GC, HbA1c

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KW - Mass spectrometry

KW - Glucosyl-ceramides

KW - Zeta-potential

KW - HPTLC

KW - Cholesterol sulfate

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Effect of type-2 diabetes on surface lipids and biophysical properties in lipoprotein populations

Abstract

Bibliographical note

Funding

Keywords

Access to Document

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