Effects of 1267 nm illumination on microcirculation regulatory mechanisms

Lyubov Eratova; Irina Makovik; Viktor Dremin

doi:10.1002/jbio.202400296

Effects of 1267 nm illumination on microcirculation regulatory mechanisms

Lyubov Eratova
, Irina Makovik
, Viktor Dremin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (SciVal)

8 Downloads (Pure)

Abstract

This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of the third finger with 1267 nm laser irradiation were evaluated. Results indicated no significant differences in perfusion between control and target measurements, likely due to blood flow redistribution caused by vessel dilation/constriction. However, differences in oscillation amplitudes in endothelial and myogenic ranges were observed, suggesting microcirculation self-regulation. Detailed analysis revealed characteristic peaks in the endothelial range during and after irradiation, indicating endothelial mediator release. It is assumed that the identified effects may be related to the singlet oxygen generated by 1267 nm laser irradiation, which directly affects the MCB, manifesting as endothelium-dependent vascular activity.

Original language	English
Article number	e202400296
Number of pages	7
Journal	Journal of Biophotonics
Volume	18
Issue number	12
Early online date	26 Nov 2024
DOIs	https://doi.org/10.1002/jbio.202400296
Publication status	Published - 1 Dec 2025

Bibliographical note

Copyright © 2024 The Author(s). Journal of Biophotonics published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Data Access Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Funding

This work was supported by Russian Science Foundation under the project No. 21-75-00086.

Funders	Funder number
Russian Science Foundation	21‐75‐00086

Keywords

1267 nm laser
blood flow oscillation
laser Doppler flowmetry
microcirculatory bed
singlet oxygen
wavelet analysis

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10.1002/jbio.202400296Licence: CC BY 4.0

Effects of 1267 nm illumination on microcirculation_Dremin_2024
Copyright © 2024 The Author(s). Journal of Biophotonics published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 3.18 MBLicence: CC BY 4.0

Cite this

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title = "Effects of 1267 nm illumination on microcirculation regulatory mechanisms",

abstract = "This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of the third finger with 1267 nm laser irradiation were evaluated. Results indicated no significant differences in perfusion between control and target measurements, likely due to blood flow redistribution caused by vessel dilation/constriction. However, differences in oscillation amplitudes in endothelial and myogenic ranges were observed, suggesting microcirculation self-regulation. Detailed analysis revealed characteristic peaks in the endothelial range during and after irradiation, indicating endothelial mediator release. It is assumed that the identified effects may be related to the singlet oxygen generated by 1267 nm laser irradiation, which directly affects the MCB, manifesting as endothelium-dependent vascular activity.",

keywords = "1267 nm laser, blood flow oscillation, laser Doppler flowmetry, microcirculatory bed, singlet oxygen, wavelet analysis",

author = "Lyubov Eratova and Irina Makovik and Viktor Dremin",

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AU - Makovik, Irina

AU - Dremin, Viktor

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PY - 2025/12/1

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N2 - This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of the third finger with 1267 nm laser irradiation were evaluated. Results indicated no significant differences in perfusion between control and target measurements, likely due to blood flow redistribution caused by vessel dilation/constriction. However, differences in oscillation amplitudes in endothelial and myogenic ranges were observed, suggesting microcirculation self-regulation. Detailed analysis revealed characteristic peaks in the endothelial range during and after irradiation, indicating endothelial mediator release. It is assumed that the identified effects may be related to the singlet oxygen generated by 1267 nm laser irradiation, which directly affects the MCB, manifesting as endothelium-dependent vascular activity.

AB - This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of the third finger with 1267 nm laser irradiation were evaluated. Results indicated no significant differences in perfusion between control and target measurements, likely due to blood flow redistribution caused by vessel dilation/constriction. However, differences in oscillation amplitudes in endothelial and myogenic ranges were observed, suggesting microcirculation self-regulation. Detailed analysis revealed characteristic peaks in the endothelial range during and after irradiation, indicating endothelial mediator release. It is assumed that the identified effects may be related to the singlet oxygen generated by 1267 nm laser irradiation, which directly affects the MCB, manifesting as endothelium-dependent vascular activity.

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KW - blood flow oscillation

KW - laser Doppler flowmetry

KW - microcirculatory bed

KW - singlet oxygen

KW - wavelet analysis

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Effects of 1267 nm illumination on microcirculation regulatory mechanisms

Abstract

Bibliographical note

Data Access Statement

Funding

Keywords

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