Effects of aqueous-supplementing artificial tears in wearers of biweekly replacement contact lenses vs wearers of daily disposable contact lenses

Silvia Tavazzi; Riccardo Origgi; Martina Anselmi; Andrea Corvino; Sara Colciago; Matteo Fagnola; Silvia Bracco; Fabrizio Zeri

doi:10.2147/OPTO.S249078

Effects of aqueous-supplementing artificial tears in wearers of biweekly replacement contact lenses vs wearers of daily disposable contact lenses

Silvia Tavazzi, Riccardo Origgi, Martina Anselmi, Andrea Corvino, Sara Colciago, Matteo Fagnola, Silvia Bracco^*, Fabrizio Zeri

^*Corresponding author for this work

College of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To compare the effects of artificial tears (ATs) in wearers of biweekly replacement silicone hydrogel contact lenses (BW-Ws) and wearers of daily disposable contact lenses (DD-Ws) of the same material.

Materials and Methods: The aqueous-supplementing ATs, OPTOyalA and OPTOidro, were assigned to be used for 2 weeks to healthy and young subjects: 1) 20 (8 and 12, respectively) BW-Ws wearing silicone hydrogel somofilcon A CLs (Clariti Elite), 2) 18 (9 and 9, respectively) DD-Ws wearing silicone hydrogel somofilcon A CLs (Clarity 1 Day), and 3) a control group of 33 (16 and 17, respectively) N-Ws. Ocular symptoms and comfort, tear volume and stability, and ocular surface condition were assessed by Ocular Surface Disease Index (OSDI), 5-Item Dry Eye Questionnaire (DEQ5), tear meniscus height (TMH), non-invasive tear break-up time (NIBUT), and evaluation of ocular redness (OR). The assessment was performed before and after 15 days of use of the ATs in the 3 groups (BW-Ws, DD-Ws, and N-Ws).

Results: No clear significant difference was noted in symptoms and signs between OPTOyalA and OPTOidro irrespectively of the group of people studied. ATs use for 15 days produced a significant improvement in DEQ5 and OR in DD-Ws (Δ=-34%, p=0.006; Δ=-23%, p<0.001) and in N-Ws (Δ=-21%, p=0.001; Δ=-10%, p=0.006) but not in BW-Ws (Δ=-5%, p=0.072; Δ=-2%, p=0.257). No significant change was noted for TMH.

Conclusion: In young and healthy subjects, the aqueous-supplementing effect of the ATs under consideration is more a rinsing and tear replacem ent effect than an increase in tear volume, and it produces an improvement of the eye redness and ocular symptoms. Contact lens wear influenced the effectiveness of ATs in a way which is correlated with the CL replacement schedule.

Original language	English
Pages (from-to)	75-84
Number of pages	10
Journal	Clinical Optometry
Volume	12
DOIs	https://doi.org/10.2147/OPTO.S249078
Publication status	Published - 25 Jun 2020

Bibliographical note

© 2020 Tavazzi et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.
php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the
work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For
permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

Keywords

Artificial tears
Contact lenses
Somofilcon A

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opto-249078-effects-of-aqueous-supplementing-artificial-tears-in-wearers_2
© 2020 Tavazzi et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
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Cite this

@article{0ced3c1c0e94480fbfecf8699ab8431a,

title = "Effects of aqueous-supplementing artificial tears in wearers of biweekly replacement contact lenses vs wearers of daily disposable contact lenses",

abstract = "Purpose: To compare the effects of artificial tears (ATs) in wearers of biweekly replacement silicone hydrogel contact lenses (BW-Ws) and wearers of daily disposable contact lenses (DD-Ws) of the same material.Materials and Methods: The aqueous-supplementing ATs, OPTOyalA and OPTOidro, were assigned to be used for 2 weeks to healthy and young subjects: 1) 20 (8 and 12, respectively) BW-Ws wearing silicone hydrogel somofilcon A CLs (Clariti Elite), 2) 18 (9 and 9, respectively) DD-Ws wearing silicone hydrogel somofilcon A CLs (Clarity 1 Day), and 3) a control group of 33 (16 and 17, respectively) N-Ws. Ocular symptoms and comfort, tear volume and stability, and ocular surface condition were assessed by Ocular Surface Disease Index (OSDI), 5-Item Dry Eye Questionnaire (DEQ5), tear meniscus height (TMH), non-invasive tear break-up time (NIBUT), and evaluation of ocular redness (OR). The assessment was performed before and after 15 days of use of the ATs in the 3 groups (BW-Ws, DD-Ws, and N-Ws).Results: No clear significant difference was noted in symptoms and signs between OPTOyalA and OPTOidro irrespectively of the group of people studied. ATs use for 15 days produced a significant improvement in DEQ5 and OR in DD-Ws (Δ=-34%, p=0.006; Δ=-23%, p<0.001) and in N-Ws (Δ=-21%, p=0.001; Δ=-10%, p=0.006) but not in BW-Ws (Δ=-5%, p=0.072; Δ=-2%, p=0.257). No significant change was noted for TMH.Conclusion: In young and healthy subjects, the aqueous-supplementing effect of the ATs under consideration is more a rinsing and tear replacem ent effect than an increase in tear volume, and it produces an improvement of the eye redness and ocular symptoms. Contact lens wear influenced the effectiveness of ATs in a way which is correlated with the CL replacement schedule.",

keywords = "Artificial tears, Contact lenses, Somofilcon A",

author = "Silvia Tavazzi and Riccardo Origgi and Martina Anselmi and Andrea Corvino and Sara Colciago and Matteo Fagnola and Silvia Bracco and Fabrizio Zeri",

note = "{\textcopyright} 2020 Tavazzi et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).",

year = "2020",

month = jun,

day = "25",

doi = "10.2147/OPTO.S249078",

language = "English",

volume = "12",

pages = "75--84",

journal = "Clinical Optometry",

issn = "0816-4622",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Effects of aqueous-supplementing artificial tears in wearers of biweekly replacement contact lenses vs wearers of daily disposable contact lenses

AU - Tavazzi, Silvia

AU - Origgi, Riccardo

AU - Anselmi, Martina

AU - Corvino, Andrea

AU - Colciago, Sara

AU - Fagnola, Matteo

AU - Bracco, Silvia

AU - Zeri, Fabrizio

N1 - © 2020 Tavazzi et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PY - 2020/6/25

Y1 - 2020/6/25

N2 - Purpose: To compare the effects of artificial tears (ATs) in wearers of biweekly replacement silicone hydrogel contact lenses (BW-Ws) and wearers of daily disposable contact lenses (DD-Ws) of the same material.Materials and Methods: The aqueous-supplementing ATs, OPTOyalA and OPTOidro, were assigned to be used for 2 weeks to healthy and young subjects: 1) 20 (8 and 12, respectively) BW-Ws wearing silicone hydrogel somofilcon A CLs (Clariti Elite), 2) 18 (9 and 9, respectively) DD-Ws wearing silicone hydrogel somofilcon A CLs (Clarity 1 Day), and 3) a control group of 33 (16 and 17, respectively) N-Ws. Ocular symptoms and comfort, tear volume and stability, and ocular surface condition were assessed by Ocular Surface Disease Index (OSDI), 5-Item Dry Eye Questionnaire (DEQ5), tear meniscus height (TMH), non-invasive tear break-up time (NIBUT), and evaluation of ocular redness (OR). The assessment was performed before and after 15 days of use of the ATs in the 3 groups (BW-Ws, DD-Ws, and N-Ws).Results: No clear significant difference was noted in symptoms and signs between OPTOyalA and OPTOidro irrespectively of the group of people studied. ATs use for 15 days produced a significant improvement in DEQ5 and OR in DD-Ws (Δ=-34%, p=0.006; Δ=-23%, p<0.001) and in N-Ws (Δ=-21%, p=0.001; Δ=-10%, p=0.006) but not in BW-Ws (Δ=-5%, p=0.072; Δ=-2%, p=0.257). No significant change was noted for TMH.Conclusion: In young and healthy subjects, the aqueous-supplementing effect of the ATs under consideration is more a rinsing and tear replacem ent effect than an increase in tear volume, and it produces an improvement of the eye redness and ocular symptoms. Contact lens wear influenced the effectiveness of ATs in a way which is correlated with the CL replacement schedule.

AB - Purpose: To compare the effects of artificial tears (ATs) in wearers of biweekly replacement silicone hydrogel contact lenses (BW-Ws) and wearers of daily disposable contact lenses (DD-Ws) of the same material.Materials and Methods: The aqueous-supplementing ATs, OPTOyalA and OPTOidro, were assigned to be used for 2 weeks to healthy and young subjects: 1) 20 (8 and 12, respectively) BW-Ws wearing silicone hydrogel somofilcon A CLs (Clariti Elite), 2) 18 (9 and 9, respectively) DD-Ws wearing silicone hydrogel somofilcon A CLs (Clarity 1 Day), and 3) a control group of 33 (16 and 17, respectively) N-Ws. Ocular symptoms and comfort, tear volume and stability, and ocular surface condition were assessed by Ocular Surface Disease Index (OSDI), 5-Item Dry Eye Questionnaire (DEQ5), tear meniscus height (TMH), non-invasive tear break-up time (NIBUT), and evaluation of ocular redness (OR). The assessment was performed before and after 15 days of use of the ATs in the 3 groups (BW-Ws, DD-Ws, and N-Ws).Results: No clear significant difference was noted in symptoms and signs between OPTOyalA and OPTOidro irrespectively of the group of people studied. ATs use for 15 days produced a significant improvement in DEQ5 and OR in DD-Ws (Δ=-34%, p=0.006; Δ=-23%, p<0.001) and in N-Ws (Δ=-21%, p=0.001; Δ=-10%, p=0.006) but not in BW-Ws (Δ=-5%, p=0.072; Δ=-2%, p=0.257). No significant change was noted for TMH.Conclusion: In young and healthy subjects, the aqueous-supplementing effect of the ATs under consideration is more a rinsing and tear replacem ent effect than an increase in tear volume, and it produces an improvement of the eye redness and ocular symptoms. Contact lens wear influenced the effectiveness of ATs in a way which is correlated with the CL replacement schedule.

KW - Artificial tears

KW - Contact lenses

KW - Somofilcon A

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UR - https://www.dovepress.com/effects-of-aqueous-supplementing-artificial-tears-in-wearers-of-biweek-peer-reviewed-article-OPTO

U2 - 10.2147/OPTO.S249078

DO - 10.2147/OPTO.S249078

M3 - Article

C2 - 32612403

AN - SCOPUS:85086921789

SN - 0816-4622

VL - 12

SP - 75

EP - 84

JO - Clinical Optometry

JF - Clinical Optometry

ER -

Effects of aqueous-supplementing artificial tears in wearers of biweekly replacement contact lenses vs wearers of daily disposable contact lenses

Abstract

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Keywords

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