Abstract
We present a report regarding the cytotoxic effects of iron-based magnetic
nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the
viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed
to determine cell viability in treated cancer cells grown under standard 2D
culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL,
and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%,
82.9%, and 75% respectively. FDG-mNPs was also shown to have a
detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%,
and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL,
and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727
and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was
visibly changed and the number of viable cells was decerased in spheroids
treated with FDG-mNPs compared with untreated spheroids. The results of
our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and
SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising
in the development of clinical applications for the destruction of cancer cells.
© 2021 by SPC (Sami Publishing Company), Asian Journal of Nanoscience and
Materials, Reproduction is permitted for noncommercial purposes.
nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the
viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed
to determine cell viability in treated cancer cells grown under standard 2D
culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL,
and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%,
82.9%, and 75% respectively. FDG-mNPs was also shown to have a
detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%,
and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL,
and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727
and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was
visibly changed and the number of viable cells was decerased in spheroids
treated with FDG-mNPs compared with untreated spheroids. The results of
our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and
SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising
in the development of clinical applications for the destruction of cancer cells.
© 2021 by SPC (Sami Publishing Company), Asian Journal of Nanoscience and
Materials, Reproduction is permitted for noncommercial purposes.
| Original language | English |
|---|---|
| Pages (from-to) | 53-66 |
| Number of pages | 13 |
| Journal | Asian Journal of Nanoscience and Materials |
| Volume | 4 |
| DOIs | |
| Publication status | Published - 1 Jan 2021 |
Bibliographical note
© 2021 by SPC (Sami Publishing Company), Asian Journal of Nanoscience andMaterials, Reproduction is permitted for noncommercial purposes.