Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function

Jason M.R. Gill, Muriel J. Caslake, Craig McAllister, Fotini Tsofliou, William R. Ferrell, Chris J. Packard, Dalia Malkova

Research output: Contribution to journalArticle

Abstract

Endurance-trained athletes experience a low level of postprandial lipaemia, but this rapidly increases with detraining. We sought to determine whether detraining-induced changes to postprandial metabolism influenced endothelial function and inflammation. Eight endurance-trained men each undertook two oral fat tolerance tests [blood taken fasted and for 6 h following a high-fat test meal (80 g fat, 80 g carbohydrate)]: one during a period of their normal training (trained) and one after 1 wk of no exercise (detrained). Endothelial function in the cutaneous microcirculation was assessed using laser Doppler imaging with iontophoresis in the fasted state and 4 h postprandially during each test. Fasting plasma triglyceride (TG) concentrations increased by 35% with detraining (P = 0.002), as did postprandial plasma (by 53%, P = 0.002), chylomicron (by 68%, P = 0.02) and very low-density lipoprotein (by 51%, P = 0.005) TG concentrations. Endothelial function decreased postprandially in both the trained (by 17%, P = 0.03) and detrained (by 22%, P = 0.03) conditions but did not differ significantly between the trained and detrained conditions in either the fasted or the postprandial states. These results suggest that, although fat ingestion induces endothelial dysfunction, interventions that alter postprandial TG metabolism will not necessarily concomitantly influence endothelial function.
Original languageEnglish
Pages (from-to)4328-4335
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number9
Early online date2 Jul 2003
DOIs
Publication statusPublished - Dec 2003

Keywords

  • acetylcholine
  • adult
  • blood glucose
  • capillaries
  • dietary fats
  • vascular endothelium
  • nonesterified fatty acids
  • vasodilator agents
  • Inflammation
  • insulin
  • interleukin-6
  • laser-doppler flowmetry
  • VLDL lipoproteins
  • tumor necrosis factor-alpha
  • nitroprusside
  • physical endurance
  • physical fitness
  • postprandial period
  • triglycerides

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