Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody

Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, Saleel Chandratre, Maria Isabel Leite, Penny Fallon, Angela Vincent, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Jacqueline Palace, Cheryl Hemingway

Research output: Contribution to journalArticle

Abstract

The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions. Morbid obesity was seen in 88% (7/8) of children of Caribbean origin. As endocrinopathies were prevalent in the majority of paediatric-onset AQP4-Ab NMOSD, endocrine surveillance and in particular early aggressive weight management is required for patients with AQP4-Ab NMOSD.

Original languageEnglish
Pages (from-to)679-684
Number of pages6
JournalMultiple Sclerosis Journal
Volume24
Issue number5
Early online date14 Aug 2017
DOIs
Publication statusPublished - 1 Apr 2018

Bibliographical note

© The Author(s), 2017. The final publication is available via Sage at http://dx.doi.org10.1177/1352458517726593

Keywords

  • Journal Article

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    Hacohen, Y., Messina, S., Gan, H-W., Wright, S., Chandratre, S., Leite, M. I., Fallon, P., Vincent, A., Ciccarelli, O., Wassmer, E., Lim, M., Palace, J., & Hemingway, C. (2018). Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody. Multiple Sclerosis Journal, 24(5), 679-684. https://doi.org/10.1177/1352458517726593