Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody

Yael Hacohen; Silvia Messina; Hoong-Wei Gan; Sukhvir Wright; Saleel Chandratre; Maria Isabel Leite; Penny Fallon; Angela Vincent; Olga Ciccarelli; Evangeline Wassmer; Ming Lim; Jacqueline Palace; Cheryl Hemingway

doi:10.1177/1352458517726593

Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody

Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, Saleel Chandratre, Maria Isabel Leite, Penny Fallon, Angela Vincent, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Jacqueline Palace, Cheryl Hemingway

College of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions. Morbid obesity was seen in 88% (7/8) of children of Caribbean origin. As endocrinopathies were prevalent in the majority of paediatric-onset AQP4-Ab NMOSD, endocrine surveillance and in particular early aggressive weight management is required for patients with AQP4-Ab NMOSD.

Original language	English
Pages (from-to)	679-684
Number of pages	6
Journal	Multiple Sclerosis Journal
Volume	24
Issue number	5
Early online date	14 Aug 2017
DOIs	https://doi.org/10.1177/1352458517726593
Publication status	Published - 1 Apr 2018

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10.1177/1352458517726593

Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody
© The Author(s), 2017. The final publication is available via Sage at http://dx.doi.org10.1177/1352458517726593
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http://discovery.ucl.ac.uk/id/eprint/1561574

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Hacohen, Y., Messina, S., Gan, H.-W., Wright, S., Chandratre, S., Leite, M. I., Fallon, P., Vincent, A., Ciccarelli, O., Wassmer, E., Lim, M., Palace, J., & Hemingway, C. (2018). Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody. Multiple Sclerosis Journal, 24(5), 679-684. https://doi.org/10.1177/1352458517726593

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abstract = "The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions. Morbid obesity was seen in 88% (7/8) of children of Caribbean origin. As endocrinopathies were prevalent in the majority of paediatric-onset AQP4-Ab NMOSD, endocrine surveillance and in particular early aggressive weight management is required for patients with AQP4-Ab NMOSD.",

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Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody

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