Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine

Vasiliy T. Lebedev; Nikolay A. Charykov; Olga S. Shemchuk; Igor V. Murin; Dmitry A. Nerukh; Andrey V. Petrov; Dmitriy N. Maystrenko; Oleg E. Molchanov; Vladimir V. Sharoyko; Konstantin N. Semenov

doi:10.1016/j.colsurfb.2023.113133

Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine

Vasiliy T. Lebedev, Nikolay A. Charykov, Olga S. Shemchuk, Igor V. Murin, Dmitry A. Nerukh, Andrey V. Petrov, Dmitriy N. Maystrenko, Oleg E. Molchanov, Vladimir V. Sharoyko^*, Konstantin N. Semenov

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.

Original language	English
Article number	113133
Number of pages	16
Journal	Colloids and Surfaces B: Biointerfaces
Volume	222
Early online date	18 Jan 2023
DOIs	https://doi.org/10.1016/j.colsurfb.2023.113133
Publication status	Published - Feb 2023

Bibliographical note

Funding Information:
This research was funded by the Russian Foundation for Basic Researches , Grant number 18-29-19008 , partially by Kurchatov Institute according to the state assignment for the theme “2.4. Carbon based nanomaterials” and by Governor Fellowship of Leningrad District personally for V.T. Lebedev (2022–2023) . The work was carried out with the financial support of the Ministry of Health of the Russian Federation “Development of molecular design and creation of drugs based on conjugates of carbon nanostructures, targeted delivery vectors and cytotoxic agents for inactivation of tumor stem cells and components of the tumor microenvironment”.

Publisher Copyright:
Copyright © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record can be found here: https://doi.org/10.1016/j.colsurfb.2023.113133

Keywords

Endometallofullerenes
Functionalization
MRI-diagnostic
Physicochemical properties

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10.1016/j.colsurfb.2023.113133

Lebedevetal_2023_AAM
Copyright © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record can be found here: https://doi.org/10.1016/j.colsurfb.2023.113133
Accepted author manuscript, 1.56 MBLicence: CC BY-NC-ND 4.0

Cite this

Lebedev, V. T., Charykov, N. A., Shemchuk, O. S., Murin, I. V., Nerukh, D. A., Petrov, A. V., Maystrenko, D. N., Molchanov, O. E., Sharoyko, V. V., & Semenov, K. N. (2023). Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine. Colloids and Surfaces B: Biointerfaces, 222, Article 113133. https://doi.org/10.1016/j.colsurfb.2023.113133

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abstract = "We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.",

keywords = "Endometallofullerenes, Functionalization, MRI-diagnostic, Physicochemical properties",

author = "Lebedev, {Vasiliy T.} and Charykov, {Nikolay A.} and Shemchuk, {Olga S.} and Murin, {Igor V.} and Nerukh, {Dmitry A.} and Petrov, {Andrey V.} and Maystrenko, {Dmitriy N.} and Molchanov, {Oleg E.} and Sharoyko, {Vladimir V.} and Semenov, {Konstantin N.}",

note = "Funding Information: This research was funded by the Russian Foundation for Basic Researches , Grant number 18-29-19008 , partially by Kurchatov Institute according to the state assignment for the theme “2.4. Carbon based nanomaterials” and by Governor Fellowship of Leningrad District personally for V.T. Lebedev (2022–2023) . The work was carried out with the financial support of the Ministry of Health of the Russian Federation “Development of molecular design and creation of drugs based on conjugates of carbon nanostructures, targeted delivery vectors and cytotoxic agents for inactivation of tumor stem cells and components of the tumor microenvironment”. Publisher Copyright: Copyright {\textcopyright} 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record can be found here: https://doi.org/10.1016/j.colsurfb.2023.113133",

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Lebedev, VT, Charykov, NA, Shemchuk, OS, Murin, IV, Nerukh, DA, Petrov, AV, Maystrenko, DN, Molchanov, OE, Sharoyko, VV & Semenov, KN 2023, 'Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine', Colloids and Surfaces B: Biointerfaces, vol. 222, 113133. https://doi.org/10.1016/j.colsurfb.2023.113133

TY - JOUR

T1 - Endometallofullerenes and their derivatives

T2 - Synthesis, physicochemical properties, and perspective application in biomedicine

AU - Lebedev, Vasiliy T.

AU - Charykov, Nikolay A.

AU - Shemchuk, Olga S.

AU - Murin, Igor V.

AU - Nerukh, Dmitry A.

AU - Petrov, Andrey V.

AU - Maystrenko, Dmitriy N.

AU - Molchanov, Oleg E.

AU - Sharoyko, Vladimir V.

AU - Semenov, Konstantin N.

N1 - Funding Information: This research was funded by the Russian Foundation for Basic Researches , Grant number 18-29-19008 , partially by Kurchatov Institute according to the state assignment for the theme “2.4. Carbon based nanomaterials” and by Governor Fellowship of Leningrad District personally for V.T. Lebedev (2022–2023) . The work was carried out with the financial support of the Ministry of Health of the Russian Federation “Development of molecular design and creation of drugs based on conjugates of carbon nanostructures, targeted delivery vectors and cytotoxic agents for inactivation of tumor stem cells and components of the tumor microenvironment”. Publisher Copyright: Copyright © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record can be found here: https://doi.org/10.1016/j.colsurfb.2023.113133

PY - 2023/2

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N2 - We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.

AB - We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.

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KW - Physicochemical properties

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Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine

Abstract

Bibliographical note

Keywords

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