We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.
|Number of pages||16|
|Journal||Colloids and Surfaces B: Biointerfaces|
|Early online date||18 Jan 2023|
|Publication status||Published - Feb 2023|
Bibliographical noteFunding Information:
This research was funded by the Russian Foundation for Basic Researches , Grant number 18-29-19008 , partially by Kurchatov Institute according to the state assignment for the theme “2.4. Carbon based nanomaterials” and by Governor Fellowship of Leningrad District personally for V.T. Lebedev (2022–2023) . The work was carried out with the financial support of the Ministry of Health of the Russian Federation “Development of molecular design and creation of drugs based on conjugates of carbon nanostructures, targeted delivery vectors and cytotoxic agents for inactivation of tumor stem cells and components of the tumor microenvironment”.
Copyright © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record can be found here: https://doi.org/10.1016/j.colsurfb.2023.113133
- Physicochemical properties