Endothelial dysfunction and preeclampsia: role of oxidative stress

Lissette Sanchez Aranguren; Carlos E. Prada; Carlos E. Riaño-Medina; Marcos López

doi:10.3389/fphys.2014.00372

Endothelial dysfunction and preeclampsia: role of oxidative stress

Lissette Sanchez Aranguren , Carlos E. Prada, Carlos E. Riaño-Medina, Marcos López

Aston Medical School

Research output: Contribution to journal › Review article › peer-review

Abstract

Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The related
poor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.

Original language	English
Article number	372
Number of pages	11
Journal	Frontiers in Physiology
Volume	5
DOIs	https://doi.org/10.3389/fphys.2014.00372
Publication status	Published - 10 Oct 2014

Bibliographical note

© 2014 Sánchez-Aranguren, Prada, Riaño-Medina and Lopez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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10.3389/fphys.2014.00372Licence: CC BY 3.0

Endothelial dysfunction and preeclampsia: role of oxidative stress
© 2014 Sánchez-Aranguren, Prada, Riaño-Medina and Lopez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Final published version, 1.29 MBLicence: CC BY 3.0

Cite this

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title = "Endothelial dysfunction and preeclampsia: role of oxidative stress",

abstract = "Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The relatedpoor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.",

author = "{Sanchez Aranguren}, Lissette and Prada, {Carlos E.} and Ria{\~n}o-Medina, {Carlos E.} and Marcos L{\'o}pez",

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AU - Sanchez Aranguren , Lissette

AU - Prada, Carlos E.

AU - Riaño-Medina, Carlos E.

AU - López, Marcos

N1 - © 2014 Sánchez-Aranguren, Prada, Riaño-Medina and Lopez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PY - 2014/10/10

Y1 - 2014/10/10

N2 - Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The relatedpoor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.

AB - Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The relatedpoor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.

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U2 - 10.3389/fphys.2014.00372

DO - 10.3389/fphys.2014.00372

M3 - Review article

SN - 1664-042X

VL - 5

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 372

ER -

Endothelial dysfunction and preeclampsia: role of oxidative stress

Abstract

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