Enhancing Transcranial Blood Flow Visualization with Dynamic Light Scattering Technologies: Advances in Quantitative Analysis

Evgeny Zherebtsov, Anton Sdobnov*, Oleksii Sieryi, Mika Kaakinen, Lauri Eklund, Teemu Myllylä, Alexander V. Bykov*, Igor Meglinski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A comparative application of major dynamic light scattering (DLS)-based image methodologies applied to transcranial cerebral blood flow imaging is presented. In particular, the study delves into assessing capability of Laser Doppler Flowmetry (LDF), Laser Speckle Contrast Imaging (LSCI), and Diffuse Correlation Spectroscopy (DCS) in enhancing the spatial and temporal resolution of transcranial blood flow imaging. An integral part of the study is focused on the modulation of blood flow through the administration of the vasodilator drug, Sodium Nitroprusside (SNP). This pharmacological intervention facilitated a direct observation of cerebral vasculature's responsiveness to external stimuli, illuminating the physiological adaptations within the brain's microvascular architecture. Advanced LSCI processing techniques are incorporated, notably entropy and principal component analysis (PCA). Entropy is providing a quantifiable measure of the randomness and complexity within the speckle patterns of transcranial blood flow images, revealing remarkably similar outcomes with DSC approach in terms of blood flow dynamics and its quantitative evaluation. The application of PCA approach is provided a more nuanced understanding of blood flow dynamics, facilitating the identification of subtle changes induced by drug administration. This method proved instrumental in enhancing the visualization and detection of nuanced blood flow dynamics, thereby allowing for a more detailed examination of cerebral circulation alterations induced by SNP administration. The study seeks to offer a wider-ranging insight into comprehending the translating further the concept of DLS into transcrainial blood flow vizualization and explore its practical applications, considering hardware, advanced quantitative image processing, and data acquisition.
Original languageEnglish
Article number2401016
Number of pages14
JournalLaser and Photonics Reviews
Early online date20 Sept 2024
DOIs
Publication statusE-pub ahead of print - 20 Sept 2024

Bibliographical note

Copyright © 2024 The Author(s). Laser & Photonics Reviews published by Wiley-VCH GmbH. This is an open access article under the terms of the
Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Data Access Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Keywords

  • anscranial visualisation
  • blood flow
  • diffuse correlation spectroscopy (DCS)
  • entropy
  • laser doppler flowmetry (LDF)
  • laser speckle contrast imageing (LSCI)
  • PCA
  • tr hemodynamics

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