Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region

Jessica Rollason; Lucy Bastin; Anthony Hilton; Devadas Pillay; Tony Worthington; Caroline McKeon; Partha De; Keith Burrows; Peter A. Lambert

doi:10.1016/j.jhin.2008.08.004

Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region

Jessica Rollason, Lucy Bastin, Anthony Hilton, Devadas Pillay, Tony Worthington, Caroline McKeon, Partha De, Keith Burrows, Peter A. Lambert

Research output: Contribution to journal › Article › peer-review

Abstract

Between January 2005 and December 2005, 199 meticillin-resistant Staphylococcus aureus (MRSA) isolates were obtained from nonhospitalised patients presenting skin and soft tissue infections to local general practitioners. The study area incorporated 57 surgeries from three Primary Care Trusts in the Lichfield, Tamworth, Burntwood, North and East Birmingham regions of Central England, UK. Following antibiotic susceptibility testing, pulsed-field gel electrophoresis, Panton-Valentine leukocidin gene detection and SCCmec element assignment, 95% of the isolates were shown to be related to hospital epidemic strains EMRSA-15 and EMRSA-16. In total 87% of the isolate population harboured SCCmec IV, 9% had SCCmec II and 4% were identified as carrying novel SCCmec IIIa-mecI. When mapped to patient home postcode, a diverse distribution of isolates harbouring SCCmec II and SCCmec IV was observed; however, the majority of isolates harbouring SCCmec IIIa-mecI were from patients residing in the north-west of the study region, highlighting a possible localised clonal group. Transmission of MRSA from the hospital setting into the surrounding community population, as demonstrated by this study, warrants the need for targeted patient screening and decolonisation in both the clinical and community environments.

Original language	English
Pages (from-to)	314-320
Number of pages	7
Journal	Journal of Hospital Infection
Volume	70
Issue number	4
DOIs	https://doi.org/10.1016/j.jhin.2008.08.004
Publication status	Published - Dec 2008

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Hospital Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Rollason, Jessica; Bastin, Lucy; Hilton, Anthony; Pillay, Devadas; Worthington, Tony; McKeon, Caroline; De, Partha; Burrows, Keith and Lambert, Peter A. (2008). Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region. Journal of Hospital Infection, 70 (4), pp. 314-320. DOI 10.1016/j.jhin.2008.08.004

Keywords

community
EMRSA-15
EMRSA-16
meticillin-resistant Staphylococcus aureus
pulsed-field gel electrophoresis
SCCmec

Access to Document

10.1016/j.jhin.2008.08.004

JHI_authors_version.pdf
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Hospital Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Rollason, Jessica; Bastin, Lucy; Hilton, Anthony; Pillay, Devadas; Worthington, Tony; McKeon, Caroline; De, Partha; Burrows, Keith and Lambert, Peter A. (2008). Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region. Journal of Hospital Infection, 70 (4), pp. 314-320. DOI 10.1016/j.jhin.2008.08.004
Licence: CC BY 3.0

http://dx.doi.org/10.1016/j.jhin.2008.08.004

Cite this

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title = "Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region",

abstract = "Between January 2005 and December 2005, 199 meticillin-resistant Staphylococcus aureus (MRSA) isolates were obtained from nonhospitalised patients presenting skin and soft tissue infections to local general practitioners. The study area incorporated 57 surgeries from three Primary Care Trusts in the Lichfield, Tamworth, Burntwood, North and East Birmingham regions of Central England, UK. Following antibiotic susceptibility testing, pulsed-field gel electrophoresis, Panton-Valentine leukocidin gene detection and SCCmec element assignment, 95% of the isolates were shown to be related to hospital epidemic strains EMRSA-15 and EMRSA-16. In total 87% of the isolate population harboured SCCmec IV, 9% had SCCmec II and 4% were identified as carrying novel SCCmec IIIa-mecI. When mapped to patient home postcode, a diverse distribution of isolates harbouring SCCmec II and SCCmec IV was observed; however, the majority of isolates harbouring SCCmec IIIa-mecI were from patients residing in the north-west of the study region, highlighting a possible localised clonal group. Transmission of MRSA from the hospital setting into the surrounding community population, as demonstrated by this study, warrants the need for targeted patient screening and decolonisation in both the clinical and community environments.",

keywords = "community, EMRSA-15, EMRSA-16, meticillin-resistant Staphylococcus aureus, pulsed-field gel electrophoresis, SCCmec",

author = "Jessica Rollason and Lucy Bastin and Anthony Hilton and Devadas Pillay and Tony Worthington and Caroline McKeon and Partha De and Keith Burrows and Lambert, {Peter A.}",

note = "NOTICE: this is the author{\textquoteright}s version of a work that was accepted for publication in Journal of Hospital Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Rollason, Jessica; Bastin, Lucy; Hilton, Anthony; Pillay, Devadas; Worthington, Tony; McKeon, Caroline; De, Partha; Burrows, Keith and Lambert, Peter A. (2008). Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region. Journal of Hospital Infection, 70 (4), pp. 314-320. DOI 10.1016/j.jhin.2008.08.004",

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AU - Rollason, Jessica

AU - Bastin, Lucy

AU - Hilton, Anthony

AU - Pillay, Devadas

AU - Worthington, Tony

AU - McKeon, Caroline

AU - De, Partha

AU - Burrows, Keith

AU - Lambert, Peter A.

N1 - NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Hospital Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Rollason, Jessica; Bastin, Lucy; Hilton, Anthony; Pillay, Devadas; Worthington, Tony; McKeon, Caroline; De, Partha; Burrows, Keith and Lambert, Peter A. (2008). Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region. Journal of Hospital Infection, 70 (4), pp. 314-320. DOI 10.1016/j.jhin.2008.08.004

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N2 - Between January 2005 and December 2005, 199 meticillin-resistant Staphylococcus aureus (MRSA) isolates were obtained from nonhospitalised patients presenting skin and soft tissue infections to local general practitioners. The study area incorporated 57 surgeries from three Primary Care Trusts in the Lichfield, Tamworth, Burntwood, North and East Birmingham regions of Central England, UK. Following antibiotic susceptibility testing, pulsed-field gel electrophoresis, Panton-Valentine leukocidin gene detection and SCCmec element assignment, 95% of the isolates were shown to be related to hospital epidemic strains EMRSA-15 and EMRSA-16. In total 87% of the isolate population harboured SCCmec IV, 9% had SCCmec II and 4% were identified as carrying novel SCCmec IIIa-mecI. When mapped to patient home postcode, a diverse distribution of isolates harbouring SCCmec II and SCCmec IV was observed; however, the majority of isolates harbouring SCCmec IIIa-mecI were from patients residing in the north-west of the study region, highlighting a possible localised clonal group. Transmission of MRSA from the hospital setting into the surrounding community population, as demonstrated by this study, warrants the need for targeted patient screening and decolonisation in both the clinical and community environments.

AB - Between January 2005 and December 2005, 199 meticillin-resistant Staphylococcus aureus (MRSA) isolates were obtained from nonhospitalised patients presenting skin and soft tissue infections to local general practitioners. The study area incorporated 57 surgeries from three Primary Care Trusts in the Lichfield, Tamworth, Burntwood, North and East Birmingham regions of Central England, UK. Following antibiotic susceptibility testing, pulsed-field gel electrophoresis, Panton-Valentine leukocidin gene detection and SCCmec element assignment, 95% of the isolates were shown to be related to hospital epidemic strains EMRSA-15 and EMRSA-16. In total 87% of the isolate population harboured SCCmec IV, 9% had SCCmec II and 4% were identified as carrying novel SCCmec IIIa-mecI. When mapped to patient home postcode, a diverse distribution of isolates harbouring SCCmec II and SCCmec IV was observed; however, the majority of isolates harbouring SCCmec IIIa-mecI were from patients residing in the north-west of the study region, highlighting a possible localised clonal group. Transmission of MRSA from the hospital setting into the surrounding community population, as demonstrated by this study, warrants the need for targeted patient screening and decolonisation in both the clinical and community environments.

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KW - EMRSA-16

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DO - 10.1016/j.jhin.2008.08.004

M3 - Article

SN - 0195-6701

VL - 70

SP - 314

EP - 320

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 4

ER -

Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region

Abstract

Bibliographical note

Keywords

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