Esculentin-1a derived peptides kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface

Medicine & Life Sciences

• esculentin steroid 100%
• Hydrophilic Contact Lens 67%
• Immobilization 50%
• Biofilms 48%
• Contact Lenses 47%
• Lenses 46%
• Pseudomonas aeruginosa 45%
• Peptides 31%
• Keratitis 28%
• Eye Infections 21%
• Bacterial Adhesion 11%
• Anura 8%
• Electron Scanning Microscopy 7%
• Tears 7%
• Ocular Vision 6%
• Pharmaceutical Preparations 6%
• Cell Count 6%
• Poisons 6%
• Bacteria 5%
• Safety 4%
• Skin 4%

Engineering & Materials Science

• Contact lenses 75%
• Biofilms 65%
• Peptides 64%
• Lenses 49%
• Pathogens 11%
• Assays 9%
• Bacteria 9%
• Drug products 8%
• Cells 7%
• Adhesion 7%
• Skin 7%
• Scanning electron microscopy 6%
• Wear of materials 5%

Chemistry

• Antibacterial 40%
• Peptide 28%
• Antipseudomonal 18%
• Diastereomer 18%
• Surface 15%
• Ocular 12%
• Percent Reduction 11%
• Polypeptide Antibiotic Agent 10%
• Mammalian Cell 10%
• Wear 9%
• Safety 8%
• Toxic 7%
• Pharmaceutical 7%
• Strain 6%
• Scanning Electron Microscopy 5%
• Reduction 4%