European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS)

Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Stella Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes & 131 others Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–butuner, Irundika Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jinjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. Mcbean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Milos Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio di Lisa, Andreas Daiber

Research output: Contribution to journalArticle

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
LanguageEnglish
Pages94-162
Number of pages69
JournalRedox biology
Volume13
Early online date18 May 2017
DOIs
Publication statusPublished - 1 Oct 2017

Fingerprint

Reactive Nitrogen Species
Oxidation-Reduction
Oxidative stress
Technology
Reactive Oxygen Species
Oxidative Stress
Medicine
Antioxidants
Research
Metabolism
Disease Progression
Therapeutics
Research Personnel

Bibliographical note

© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).

Funding: COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks.

Keywords

  • antioxidants
  • oxidative stress
  • reactive nitrogen species
  • reactive oxygen species
  • redox signaling
  • redox therapeutics

Cite this

Egea, Javier ; Fabregat, Isabel ; Frapart, Yves M. ; Ghezzi, Pietro ; Görlach, Agnes ; Kietzmann, Thomas ; Kubaichuk, Kateryna ; Knaus, Ulla G. ; Lopez, Manuela G. ; Olaso-Gonzalez, Gloria ; Petry, Andreas ; Schulz, Rainer ; Vina, Jose ; Winyard, Paul ; Abbas, Kahina ; Ademowo, Stella ; Afonso, Catarina B. ; Andreadou, Ioanna ; Antelmann, Haike ; Antunes, Fernando ; Aslan, Mutay ; Bachschmid, Markus M. ; Barbosa, Rui M. ; Belousov, Vsevolod ; Berndt, Carsten ; Bernlohr, David ; Bertrán, Esther ; Bindoli, Alberto ; Bottari, Serge P. ; Brito, Paula M. ; Carrara, Guia ; Casas, Ana I. ; Chatzi, Afroditi ; Chondrogianni, Niki ; Conrad, Marcus ; Cooke, Marcus S. ; Costa, João G. ; Cuadrado, Antonio ; My-Chan Dang, Pham ; De Smet, Barbara ; Debelec–butuner, Bilge ; Dias, Irundika ; Dunn, Joe Dan ; Edson, Amanda J. ; El Assar, Mariam ; El-Benna, Jamel ; Ferdinandy, Péter ; Fernandes, Ana S. ; Fladmark, Kari E. ; Förstermann, Ulrich ; Giniatullin, Rashid ; Giricz, Zoltán ; Görbe, Anikó ; Griffiths, Helen ; Hampl, Vaclav ; Hanf, Alina ; Herget, Jan ; Hernansanz-Agustín, Pablo ; Hillion, Melanie ; Huang, Jinjing ; Ilikay, Serap ; Jansen-Dürr, Pidder ; Jaquet, Vincent ; Joles, Jaap A. ; Kalyanaraman, Balaraman ; Kaminskyy, Danylo ; Karbaschi, Mahsa ; Kleanthous, Marina ; Klotz, Lars-Oliver ; Korac, Bato ; Korkmaz, Kemal Sami ; Koziel, Rafal ; Kračun, Damir ; Krause, Karl-Heinz ; Křen, Vladimír ; Krieg, Thomas ; Laranjinha, João ; Lazou, Antigone ; Li, Huige ; Martínez-Ruiz, Antonio ; Matsui, Reiko ; Mcbean, Gethin J. ; Meredith, Stuart P. ; Messens, Joris ; Miguel, Verónica ; Mikhed, Yuliya ; Milisav, Irina ; Milković, Lidija ; Miranda-Vizuete, Antonio ; Mojović, Milos ; Monsalve, María ; Mouthuy, Pierre-Alexis ; Mulvey, John ; Münzel, Thomas ; Muzykantov, Vladimir ; Nguyen, Isabel T.N. ; Oelze, Matthias ; Oliveira, Nuno G. ; Palmeira, Carlos M. ; Papaevgeniou, Nikoletta ; Pavićević, Aleksandra ; Pedre, Brandán ; Peyrot, Fabienne ; Phylactides, Marios ; Pircalabioru, Gratiela G. ; Pitt, Andrew R. ; Poulsen, Henrik E. ; Prieto, Ignacio ; Rigobello, Maria Pia ; Robledinos-Antón, Natalia ; Rodríguez-mañas, Leocadio ; Rolo, Anabela P. ; Rousset, Francis ; Ruskovska, Tatjana ; Saraiva, Nuno ; Sasson, Shlomo ; Schröder, Katrin ; Semen, Khrystyna ; Seredenina, Tamara ; Shakirzyanova, Anastasia ; Smith, Geoffrey L. ; Soldati, Thierry ; Sousa, Bebiana C. ; Spickett, Corinne M. ; Stancic, Ana ; Stasia, Marie José ; Steinbrenner, Holger ; Stepanić, Višnja ; Steven, Sebastian ; Tokatlidis, Kostas ; Tuncay, Erkan ; Turan, Belma ; Ursini, Fulvio ; Vacek, Jan ; Vajnerova, Olga ; Valentová, Kateřina ; van Breusegem, Frank ; Varisli, Lokman ; Veal, Elizabeth A. ; Yalçın, A. Suha ; Yelisyeyeva, Olha ; Žarković, Neven ; Zatloukalová, Martina ; Zielonka, Jacek ; Touyz, Rhian M. ; Papapetropoulos, Andreas ; Grune, Tilman ; Lamas, Santiago ; Schmidt, Harald H.H.W. ; di Lisa, Fabio ; Daiber, Andreas. / European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS). In: Redox biology. 2017 ; Vol. 13. pp. 94-162.
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abstract = "The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.",
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Egea, J, Fabregat, I, Frapart, YM, Ghezzi, P, Görlach, A, Kietzmann, T, Kubaichuk, K, Knaus, UG, Lopez, MG, Olaso-Gonzalez, G, Petry, A, Schulz, R, Vina, J, Winyard, P, Abbas, K, Ademowo, S, Afonso, CB, Andreadou, I, Antelmann, H, Antunes, F, Aslan, M, Bachschmid, MM, Barbosa, RM, Belousov, V, Berndt, C, Bernlohr, D, Bertrán, E, Bindoli, A, Bottari, SP, Brito, PM, Carrara, G, Casas, AI, Chatzi, A, Chondrogianni, N, Conrad, M, Cooke, MS, Costa, JG, Cuadrado, A, My-Chan Dang, P, De Smet, B, Debelec–butuner, B, Dias, I, Dunn, JD, Edson, AJ, El Assar, M, El-Benna, J, Ferdinandy, P, Fernandes, AS, Fladmark, KE, Förstermann, U, Giniatullin, R, Giricz, Z, Görbe, A, Griffiths, H, Hampl, V, Hanf, A, Herget, J, Hernansanz-Agustín, P, Hillion, M, Huang, J, Ilikay, S, Jansen-Dürr, P, Jaquet, V, Joles, JA, Kalyanaraman, B, Kaminskyy, D, Karbaschi, M, Kleanthous, M, Klotz, L-O, Korac, B, Korkmaz, KS, Koziel, R, Kračun, D, Krause, K-H, Křen, V, Krieg, T, Laranjinha, J, Lazou, A, Li, H, Martínez-Ruiz, A, Matsui, R, Mcbean, GJ, Meredith, SP, Messens, J, Miguel, V, Mikhed, Y, Milisav, I, Milković, L, Miranda-Vizuete, A, Mojović, M, Monsalve, M, Mouthuy, P-A, Mulvey, J, Münzel, T, Muzykantov, V, Nguyen, ITN, Oelze, M, Oliveira, NG, Palmeira, CM, Papaevgeniou, N, Pavićević, A, Pedre, B, Peyrot, F, Phylactides, M, Pircalabioru, GG, Pitt, AR, Poulsen, HE, Prieto, I, Rigobello, MP, Robledinos-Antón, N, Rodríguez-mañas, L, Rolo, AP, Rousset, F, Ruskovska, T, Saraiva, N, Sasson, S, Schröder, K, Semen, K, Seredenina, T, Shakirzyanova, A, Smith, GL, Soldati, T, Sousa, BC, Spickett, CM, Stancic, A, Stasia, MJ, Steinbrenner, H, Stepanić, V, Steven, S, Tokatlidis, K, Tuncay, E, Turan, B, Ursini, F, Vacek, J, Vajnerova, O, Valentová, K, van Breusegem, F, Varisli, L, Veal, EA, Yalçın, AS, Yelisyeyeva, O, Žarković, N, Zatloukalová, M, Zielonka, J, Touyz, RM, Papapetropoulos, A, Grune, T, Lamas, S, Schmidt, HHHW, di Lisa, F & Daiber, A 2017, 'European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS)' Redox biology, vol. 13, pp. 94-162. https://doi.org/10.1016/j.redox.2017.05.007

European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS). / Egea, Javier; Fabregat, Isabel; Frapart, Yves M.; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G.; Lopez, Manuela G.; Olaso-Gonzalez, Gloria; Petry, Andreas; Schulz, Rainer; Vina, Jose; Winyard, Paul; Abbas, Kahina; Ademowo, Stella; Afonso, Catarina B.; Andreadou, Ioanna; Antelmann, Haike; Antunes, Fernando; Aslan, Mutay; Bachschmid, Markus M.; Barbosa, Rui M.; Belousov, Vsevolod; Berndt, Carsten; Bernlohr, David; Bertrán, Esther; Bindoli, Alberto; Bottari, Serge P.; Brito, Paula M.; Carrara, Guia; Casas, Ana I.; Chatzi, Afroditi; Chondrogianni, Niki; Conrad, Marcus; Cooke, Marcus S.; Costa, João G.; Cuadrado, Antonio; My-Chan Dang, Pham; De Smet, Barbara; Debelec–butuner, Bilge; Dias, Irundika; Dunn, Joe Dan; Edson, Amanda J.; El Assar, Mariam; El-Benna, Jamel; Ferdinandy, Péter; Fernandes, Ana S.; Fladmark, Kari E.; Förstermann, Ulrich; Giniatullin, Rashid; Giricz, Zoltán; Görbe, Anikó; Griffiths, Helen; Hampl, Vaclav; Hanf, Alina; Herget, Jan; Hernansanz-Agustín, Pablo; Hillion, Melanie; Huang, Jinjing; Ilikay, Serap; Jansen-Dürr, Pidder; Jaquet, Vincent; Joles, Jaap A.; Kalyanaraman, Balaraman; Kaminskyy, Danylo; Karbaschi, Mahsa; Kleanthous, Marina; Klotz, Lars-Oliver; Korac, Bato; Korkmaz, Kemal Sami; Koziel, Rafal; Kračun, Damir; Krause, Karl-Heinz; Křen, Vladimír; Krieg, Thomas; Laranjinha, João; Lazou, Antigone; Li, Huige; Martínez-Ruiz, Antonio; Matsui, Reiko; Mcbean, Gethin J.; Meredith, Stuart P.; Messens, Joris; Miguel, Verónica; Mikhed, Yuliya; Milisav, Irina; Milković, Lidija; Miranda-Vizuete, Antonio; Mojović, Milos; Monsalve, María; Mouthuy, Pierre-Alexis; Mulvey, John; Münzel, Thomas; Muzykantov, Vladimir; Nguyen, Isabel T.N.; Oelze, Matthias; Oliveira, Nuno G.; Palmeira, Carlos M.; Papaevgeniou, Nikoletta; Pavićević, Aleksandra; Pedre, Brandán; Peyrot, Fabienne; Phylactides, Marios; Pircalabioru, Gratiela G.; Pitt, Andrew R.; Poulsen, Henrik E.; Prieto, Ignacio; Rigobello, Maria Pia; Robledinos-Antón, Natalia; Rodríguez-mañas, Leocadio; Rolo, Anabela P.; Rousset, Francis; Ruskovska, Tatjana; Saraiva, Nuno; Sasson, Shlomo; Schröder, Katrin; Semen, Khrystyna; Seredenina, Tamara; Shakirzyanova, Anastasia; Smith, Geoffrey L.; Soldati, Thierry; Sousa, Bebiana C.; Spickett, Corinne M.; Stancic, Ana; Stasia, Marie José; Steinbrenner, Holger; Stepanić, Višnja; Steven, Sebastian; Tokatlidis, Kostas; Tuncay, Erkan; Turan, Belma; Ursini, Fulvio; Vacek, Jan; Vajnerova, Olga; Valentová, Kateřina; van Breusegem, Frank; Varisli, Lokman; Veal, Elizabeth A.; Yalçın, A. Suha; Yelisyeyeva, Olha; Žarković, Neven; Zatloukalová, Martina; Zielonka, Jacek; Touyz, Rhian M.; Papapetropoulos, Andreas; Grune, Tilman; Lamas, Santiago; Schmidt, Harald H.H.W.; di Lisa, Fabio; Daiber, Andreas.

In: Redox biology, Vol. 13, 01.10.2017, p. 94-162.

Research output: Contribution to journalArticle

TY - JOUR

T1 - European contribution to the study of ROS

T2 - Redox biology

AU - Egea, Javier

AU - Fabregat, Isabel

AU - Frapart, Yves M.

AU - Ghezzi, Pietro

AU - Görlach, Agnes

AU - Kietzmann, Thomas

AU - Kubaichuk, Kateryna

AU - Knaus, Ulla G.

AU - Lopez, Manuela G.

AU - Olaso-Gonzalez, Gloria

AU - Petry, Andreas

AU - Schulz, Rainer

AU - Vina, Jose

AU - Winyard, Paul

AU - Abbas, Kahina

AU - Ademowo, Stella

AU - Afonso, Catarina B.

AU - Andreadou, Ioanna

AU - Antelmann, Haike

AU - Antunes, Fernando

AU - Aslan, Mutay

AU - Bachschmid, Markus M.

AU - Barbosa, Rui M.

AU - Belousov, Vsevolod

AU - Berndt, Carsten

AU - Bernlohr, David

AU - Bertrán, Esther

AU - Bindoli, Alberto

AU - Bottari, Serge P.

AU - Brito, Paula M.

AU - Carrara, Guia

AU - Casas, Ana I.

AU - Chatzi, Afroditi

AU - Chondrogianni, Niki

AU - Conrad, Marcus

AU - Cooke, Marcus S.

AU - Costa, João G.

AU - Cuadrado, Antonio

AU - My-Chan Dang, Pham

AU - De Smet, Barbara

AU - Debelec–butuner, Bilge

AU - Dias, Irundika

AU - Dunn, Joe Dan

AU - Edson, Amanda J.

AU - El Assar, Mariam

AU - El-Benna, Jamel

AU - Ferdinandy, Péter

AU - Fernandes, Ana S.

AU - Fladmark, Kari E.

AU - Förstermann, Ulrich

AU - Giniatullin, Rashid

AU - Giricz, Zoltán

AU - Görbe, Anikó

AU - Griffiths, Helen

AU - Hampl, Vaclav

AU - Hanf, Alina

AU - Herget, Jan

AU - Hernansanz-Agustín, Pablo

AU - Hillion, Melanie

AU - Huang, Jinjing

AU - Ilikay, Serap

AU - Jansen-Dürr, Pidder

AU - Jaquet, Vincent

AU - Joles, Jaap A.

AU - Kalyanaraman, Balaraman

AU - Kaminskyy, Danylo

AU - Karbaschi, Mahsa

AU - Kleanthous, Marina

AU - Klotz, Lars-Oliver

AU - Korac, Bato

AU - Korkmaz, Kemal Sami

AU - Koziel, Rafal

AU - Kračun, Damir

AU - Krause, Karl-Heinz

AU - Křen, Vladimír

AU - Krieg, Thomas

AU - Laranjinha, João

AU - Lazou, Antigone

AU - Li, Huige

AU - Martínez-Ruiz, Antonio

AU - Matsui, Reiko

AU - Mcbean, Gethin J.

AU - Meredith, Stuart P.

AU - Messens, Joris

AU - Miguel, Verónica

AU - Mikhed, Yuliya

AU - Milisav, Irina

AU - Milković, Lidija

AU - Miranda-Vizuete, Antonio

AU - Mojović, Milos

AU - Monsalve, María

AU - Mouthuy, Pierre-Alexis

AU - Mulvey, John

AU - Münzel, Thomas

AU - Muzykantov, Vladimir

AU - Nguyen, Isabel T.N.

AU - Oelze, Matthias

AU - Oliveira, Nuno G.

AU - Palmeira, Carlos M.

AU - Papaevgeniou, Nikoletta

AU - Pavićević, Aleksandra

AU - Pedre, Brandán

AU - Peyrot, Fabienne

AU - Phylactides, Marios

AU - Pircalabioru, Gratiela G.

AU - Pitt, Andrew R.

AU - Poulsen, Henrik E.

AU - Prieto, Ignacio

AU - Rigobello, Maria Pia

AU - Robledinos-Antón, Natalia

AU - Rodríguez-mañas, Leocadio

AU - Rolo, Anabela P.

AU - Rousset, Francis

AU - Ruskovska, Tatjana

AU - Saraiva, Nuno

AU - Sasson, Shlomo

AU - Schröder, Katrin

AU - Semen, Khrystyna

AU - Seredenina, Tamara

AU - Shakirzyanova, Anastasia

AU - Smith, Geoffrey L.

AU - Soldati, Thierry

AU - Sousa, Bebiana C.

AU - Spickett, Corinne M.

AU - Stancic, Ana

AU - Stasia, Marie José

AU - Steinbrenner, Holger

AU - Stepanić, Višnja

AU - Steven, Sebastian

AU - Tokatlidis, Kostas

AU - Tuncay, Erkan

AU - Turan, Belma

AU - Ursini, Fulvio

AU - Vacek, Jan

AU - Vajnerova, Olga

AU - Valentová, Kateřina

AU - van Breusegem, Frank

AU - Varisli, Lokman

AU - Veal, Elizabeth A.

AU - Yalçın, A. Suha

AU - Yelisyeyeva, Olha

AU - Žarković, Neven

AU - Zatloukalová, Martina

AU - Zielonka, Jacek

AU - Touyz, Rhian M.

AU - Papapetropoulos, Andreas

AU - Grune, Tilman

AU - Lamas, Santiago

AU - Schmidt, Harald H.H.W.

AU - di Lisa, Fabio

AU - Daiber, Andreas

N1 - © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Funding: COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

AB - The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

KW - antioxidants

KW - oxidative stress

KW - reactive nitrogen species

KW - reactive oxygen species

KW - redox signaling

KW - redox therapeutics

UR - http://www.scopus.com/inward/record.url?scp=85020032301&partnerID=8YFLogxK

U2 - 10.1016/j.redox.2017.05.007

DO - 10.1016/j.redox.2017.05.007

M3 - Article

VL - 13

SP - 94

EP - 162

JO - Redox biology

JF - Redox biology

SN - 2213-2317

ER -