Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study

E.J. Williams; L. Mair; T.I. de Silva; Dan Green; P. House; K. Cawthorn; C. Gillies; J. Wigfull; H. Parsons; D.G. Partridge

doi:10.1016/j.jhin.2021.01.006

Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study

E.J. Williams, L. Mair, T.I. de Silva, Dan Green, P. House, K. Cawthorn, C. Gillies, J. Wigfull, H. Parsons, D.G. Partridge

Research output: Contribution to journal › Article › peer-review

52 Citations (SciVal)

Abstract

It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting.

Original language	English
Pages (from-to)	103-107
Number of pages	5
Journal	Journal of Hospital Infection
Volume	110
Early online date	20 Jan 2021
DOIs	https://doi.org/10.1016/j.jhin.2021.01.006
Publication status	Published - Apr 2021

Access to Document

10.1016/j.jhin.2021.01.006

Cite this

@article{477afe4f7a834f3c8b19935703f6e5d2,

title = "Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study",

abstract = "It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting.",

author = "E.J. Williams and L. Mair and {de Silva}, T.I. and Dan Green and P. House and K. Cawthorn and C. Gillies and J. Wigfull and H. Parsons and D.G. Partridge",

year = "2021",

month = apr,

doi = "10.1016/j.jhin.2021.01.006",

language = "English",

volume = "110",

pages = "103--107",

journal = "Journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study

AU - Williams, E.J.

AU - Mair, L.

AU - de Silva, T.I.

AU - Green, Dan

AU - House, P.

AU - Cawthorn, K.

AU - Gillies, C.

AU - Wigfull, J.

AU - Parsons, H.

AU - Partridge, D.G.

PY - 2021/4

Y1 - 2021/4

N2 - It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting.

AB - It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting.

UR - https://www.sciencedirect.com/science/article/pii/S0195670121000232?via%3Dihub

U2 - 10.1016/j.jhin.2021.01.006

DO - 10.1016/j.jhin.2021.01.006

M3 - Article

SN - 0195-6701

VL - 110

SP - 103

EP - 107

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

ER -

Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study

Abstract

Access to Document

Other files and links

Fingerprint

Cite this