Evaluation of the effectiveness and acceptability of intramuscular clozapine injection: illustrative case series

Rebecca Henry; Ruth Massey; Kathy Morgan; Johanne Deeks; Hannah MacFarlane; Nikki Holmes; Edward Silva

doi:10.1192/bjb.2020.6

Evaluation of the effectiveness and acceptability of intramuscular clozapine injection: illustrative case series

Rebecca Henry, Ruth Massey, Kathy Morgan, Johanne Deeks, Hannah MacFarlane, Nikki Holmes, Edward Silva

Research output: Contribution to journal › Article › peer-review

Abstract

Aims and method: A series of eleven patients prescribed intramuscular clozapine at five UK sites is presented. Using routinely collected clinical data, we describe the use, efficacy and safety of this treatment modality.

Results: We administered 188 doses of intramuscular clozapine to eight patients. The remaining three patients accepted oral medication. With the exception of minor injection site pain and nodules, side-effects were as expected with oral clozapine, and there were no serious untoward events. Nine patients were successfully established on oral clozapine with significant improvement in their clinical presentations.

Clinical implications: Although a novel formulation in the UK, we have shown that intramuscular clozapine can be used safely and effectively when the oral route is initially refused.

Original language	English
Pages (from-to)	239-243
Number of pages	5
Journal	BJPsych Bulletin
Volume	44
Issue number	6
DOIs	https://doi.org/10.1192/bjb.2020.6
Publication status	Published - 21 Feb 2020

Bibliographical note

Copyright © The Authors 2020. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Clozapine
intramuscular
schizophrenia
treatment refusal

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evaluation-of-the-effectiveness-and-acceptability-of-intramuscular-clozapine-injection-illustrative-case-series (1)
Copyright © The Authors 2020. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 568 KBLicence: CC BY 3.0

Cite this

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abstract = "Aims and method: A series of eleven patients prescribed intramuscular clozapine at five UK sites is presented. Using routinely collected clinical data, we describe the use, efficacy and safety of this treatment modality. Results: We administered 188 doses of intramuscular clozapine to eight patients. The remaining three patients accepted oral medication. With the exception of minor injection site pain and nodules, side-effects were as expected with oral clozapine, and there were no serious untoward events. Nine patients were successfully established on oral clozapine with significant improvement in their clinical presentations. Clinical implications: Although a novel formulation in the UK, we have shown that intramuscular clozapine can be used safely and effectively when the oral route is initially refused. ",

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AU - Holmes, Nikki

AU - Silva, Edward

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Evaluation of the effectiveness and acceptability of intramuscular clozapine injection: illustrative case series

Abstract

Bibliographical note

Keywords

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