Evidence for the early clinical relevance of hallucinatory-delusional states in the general population

R. Nuevo, J. van Os, C. Arango, S. Chatterji, J.L. Ayuso-Mateos

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To analyze, in a general population sample, clustering of delusional and hallucinatory experiences in relation to environmental exposures and clinical parameters.

METHOD: General population-based household surveys of randomly selected adults between 18 and 65 years of age were carried out.

SETTING: 52 countries participating in the World Health Organization's World Health Survey were included.

PARTICIPANTS: 225 842 subjects (55.6% women), from nationally representative samples, with an individual response rate of 98.5% within households participated.

RESULTS: Compared with isolated delusions and hallucinations, co-occurrence of the two phenomena was associated with poorer outcome including worse general health and functioning status (OR = 0.93; 95% CI: 0.92-0.93), greater severity of symptoms (OR = 2.5 95% CI: 2.0-3.0), higher probability of lifetime diagnosis of psychotic disorder (OR = 12.9; 95% CI: 11.5-14.4), lifetime treatment for psychotic disorder (OR = 19.7; 95% CI: 17.3-22.5), and depression during the last 12 months (OR = 11.6; 95% CI: 10.9-12.4). Co-occurrence was also associated with adversity and hearing problems (OR = 2.0; 95% CI: 1.8-2.3).

CONCLUSION: The results suggest that the co-occurrence of hallucinations and delusions in populations is not random but instead can be seen, compared with either phenomenon in isolation, as the result of more etiologic loading leading to a more severe clinical state.

Original languageEnglish
Pages (from-to)482-493
Number of pages12
JournalActa Psychiatrica Scandinavica
Volume127
Issue number6
Early online date4 Sep 2012
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Delusions
Hallucinations
Psychotic Disorders
Population
Environmental Exposure
Health Surveys
Hearing
Health Status
Cluster Analysis
Depression
Therapeutics
Global Health
Surveys and Questionnaires

Keywords

  • adolescent
  • unemployment
  • risk factors
  • comorbidity
  • cross-sectional studies
  • delusions
  • depression
  • hearing disorders
  • hallucinations
  • health status
  • health surveys
  • severity of illness index
  • psychotic disorders
  • violence
  • World Health Organization

Cite this

Nuevo, R. ; van Os, J. ; Arango, C. ; Chatterji, S. ; Ayuso-Mateos, J.L. / Evidence for the early clinical relevance of hallucinatory-delusional states in the general population. In: Acta Psychiatrica Scandinavica. 2013 ; Vol. 127, No. 6. pp. 482-493.
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abstract = "OBJECTIVE: To analyze, in a general population sample, clustering of delusional and hallucinatory experiences in relation to environmental exposures and clinical parameters.METHOD: General population-based household surveys of randomly selected adults between 18 and 65 years of age were carried out.SETTING: 52 countries participating in the World Health Organization's World Health Survey were included.PARTICIPANTS: 225 842 subjects (55.6{\%} women), from nationally representative samples, with an individual response rate of 98.5{\%} within households participated.RESULTS: Compared with isolated delusions and hallucinations, co-occurrence of the two phenomena was associated with poorer outcome including worse general health and functioning status (OR = 0.93; 95{\%} CI: 0.92-0.93), greater severity of symptoms (OR = 2.5 95{\%} CI: 2.0-3.0), higher probability of lifetime diagnosis of psychotic disorder (OR = 12.9; 95{\%} CI: 11.5-14.4), lifetime treatment for psychotic disorder (OR = 19.7; 95{\%} CI: 17.3-22.5), and depression during the last 12 months (OR = 11.6; 95{\%} CI: 10.9-12.4). Co-occurrence was also associated with adversity and hearing problems (OR = 2.0; 95{\%} CI: 1.8-2.3).CONCLUSION: The results suggest that the co-occurrence of hallucinations and delusions in populations is not random but instead can be seen, compared with either phenomenon in isolation, as the result of more etiologic loading leading to a more severe clinical state.",
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Evidence for the early clinical relevance of hallucinatory-delusional states in the general population. / Nuevo, R.; van Os, J.; Arango, C.; Chatterji, S.; Ayuso-Mateos, J.L.

In: Acta Psychiatrica Scandinavica, Vol. 127, No. 6, 06.2013, p. 482-493.

Research output: Contribution to journalArticle

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T1 - Evidence for the early clinical relevance of hallucinatory-delusional states in the general population

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AU - van Os, J.

AU - Arango, C.

AU - Chatterji, S.

AU - Ayuso-Mateos, J.L.

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KW - unemployment

KW - risk factors

KW - comorbidity

KW - cross-sectional studies

KW - delusions

KW - depression

KW - hearing disorders

KW - hallucinations

KW - health status

KW - health surveys

KW - severity of illness index

KW - psychotic disorders

KW - violence

KW - World Health Organization

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JO - Acta Psychiatrica Scandinavica

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