Exploring the Interplay between Carotenoids, Lipid Oxidation, and Cognitive Impairment in Aging

Irundika HK Dias; Sewa Abdullah; Lena Pickert; Alexander Thimm; Dumindri Abeysena; Joris Deelen; Helen R Griffiths; Maria Cristina Polidori

doi:10.1002/alz.087972

Exploring the Interplay between Carotenoids, Lipid Oxidation, and Cognitive Impairment in Aging

Irundika HK Dias, Sewa Abdullah, Lena Pickert, Alexander Thimm, Dumindri Abeysena, Joris Deelen, Helen R Griffiths, Maria Cristina Polidori

Institute of Healthy Ageing, University College London, Department of Genetics, Evolution and Environment, Darwin Building, Gower Street, London WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany

Research output: Contribution to journal › Conference article › peer-review

Abstract

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory loss, and impaired daily functioning. As the global population ages, the prevalence of AD continues to rise, emphasising the urgent need for effective preventive and therapeutic strategies. Carotenoids, a group of naturally occurring pigments with antioxidant properties, have gained attention for their potential neuroprotective effects. Carotenoids interrupt the oxidative process by scavenging free radicals and quenching singlet oxygen, ultimately reducing lipid oxidation and preserving the integrity of lipids in biological systems. This project investigated the relationship between blood carotenoid levels, lipid oxidation and their impact on cognitive impairment.

Original language	English
Number of pages	2
Journal	Alzheimer's & Dementia
Volume	20
Issue number	S2
Early online date	9 Jan 2025
DOIs	https://doi.org/10.1002/alz.087972
Publication status	Published - 9 Jan 2025

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided
the original work is properly cited.
© 2024 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association

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title = "Exploring the Interplay between Carotenoids, Lipid Oxidation, and Cognitive Impairment in Aging",

abstract = "Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory loss, and impaired daily functioning. As the global population ages, the prevalence of AD continues to rise, emphasising the urgent need for effective preventive and therapeutic strategies. Carotenoids, a group of naturally occurring pigments with antioxidant properties, have gained attention for their potential neuroprotective effects. Carotenoids interrupt the oxidative process by scavenging free radicals and quenching singlet oxygen, ultimately reducing lipid oxidation and preserving the integrity of lipids in biological systems. This project investigated the relationship between blood carotenoid levels, lipid oxidation and their impact on cognitive impairment.",

author = "Dias, {Irundika HK} and Sewa Abdullah and Lena Pickert and Alexander Thimm and Dumindri Abeysena and Joris Deelen and Griffiths, {Helen R} and Polidori, {Maria Cristina}",

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AU - Dias, Irundika HK

AU - Abdullah, Sewa

AU - Pickert, Lena

AU - Thimm, Alexander

AU - Abeysena, Dumindri

AU - Deelen, Joris

AU - Griffiths, Helen R

AU - Polidori, Maria Cristina

N1 - This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association

PY - 2025/1/9

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N2 - Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory loss, and impaired daily functioning. As the global population ages, the prevalence of AD continues to rise, emphasising the urgent need for effective preventive and therapeutic strategies. Carotenoids, a group of naturally occurring pigments with antioxidant properties, have gained attention for their potential neuroprotective effects. Carotenoids interrupt the oxidative process by scavenging free radicals and quenching singlet oxygen, ultimately reducing lipid oxidation and preserving the integrity of lipids in biological systems. This project investigated the relationship between blood carotenoid levels, lipid oxidation and their impact on cognitive impairment.

AB - Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory loss, and impaired daily functioning. As the global population ages, the prevalence of AD continues to rise, emphasising the urgent need for effective preventive and therapeutic strategies. Carotenoids, a group of naturally occurring pigments with antioxidant properties, have gained attention for their potential neuroprotective effects. Carotenoids interrupt the oxidative process by scavenging free radicals and quenching singlet oxygen, ultimately reducing lipid oxidation and preserving the integrity of lipids in biological systems. This project investigated the relationship between blood carotenoid levels, lipid oxidation and their impact on cognitive impairment.

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U2 - 10.1002/alz.087972

DO - 10.1002/alz.087972

M3 - Conference article

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IS - S2

ER -

Exploring the Interplay between Carotenoids, Lipid Oxidation, and Cognitive Impairment in Aging

Abstract

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