Keyphrases
Mechanism of Action
100%
Computational Approach
100%
Cyclin-dependent Kinase 2 (CDK2)
100%
Spirooxindole
100%
Inhibitory Mechanism
15%
T-loop Phosphorylation
15%
Phosphorylation
7%
Protein Structure
7%
Cell Proliferation
7%
Binding Affinity
7%
Oncogenesis
7%
Kinase Activation
7%
Molecular Dynamics Simulation
7%
Binding Energy
7%
Phosphorylation Sites
7%
Molecular Mechanics
7%
Molecular Docking
7%
Mitosis
7%
Cancer Cells
7%
Binding Residues
7%
Docking Dynamics
7%
Inhibitor Binding
7%
Protein Signaling Pathways
7%
Druggability
7%
Key Binding
7%
Energy Decomposition Analysis
7%
Cell Cycle Checkpoint
7%
Active Loop
7%
Spirooxindole Scaffold
7%
Structure-based Approaches
7%
Cancer Cell Proliferation
7%
Chemistry
Spirooxindole
100%
phosphorylation
60%
Kd
20%
Free Energy
20%
Molecular Dynamics
20%
Molecular Mechanic
20%
Protein Structure
20%
Pharmacology, Toxicology and Pharmaceutical Science
Cyclin Dependent Kinase 2
100%
Cyclin Dependent Kinase 2 Inhibitor
100%
Phosphotransferase
11%
Malignant Neoplasm
11%
Carcinogenesis
11%
Molecular Mechanic
11%
Hexachlorophene
11%
Biochemistry, Genetics and Molecular Biology
Cyclin-Dependent Kinase 2
100%
Cell Proliferation
15%
Kinase
7%
Phosphotransferase
7%
Protein Structure
7%
Binding Affinity
7%
Active Site
7%
Molecular Mechanic
7%
Cell Cycle Checkpoint
7%
Docking (Molecular)
7%
Cancer Cell
7%
Signaling Protein
7%
Carcinogenesis
7%
Chemical Engineering
Free Energy
100%
Molecular Mechanics
100%