Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function

Keyphrases

• Calcitonin Receptor 100%
• G Protein-coupled Receptor 100%
• CGRP Receptor 100%
• Receptor Function 100%
• Transmembrane Region 100%
• Extracellular Loop 100%
• Receptor Activation 33%
• Adenylate Cyclase 33%
• Binding Site 33%
• Cell Surface Receptor 33%
• Ligand Binding 33%
• Ligand-receptor Binding 33%
• Leucine 33%
• Signal Transduction 33%
• Transmembrane Domain 33%
• Receptor Activity-modifying Protein 33%
• RAMP1 33%
• Rhodopsin 33%
• Receptor Expression 33%
• Binding Interface 33%
• Activation Mechanism 33%
• Reduced Cell 33%
• Rational Drug Design 33%
• Binding Function 33%
• ECL2 33%
• Secretin 33%
• Receptor System 33%
• Minor Groove 33%
• Hydrophobic Cluster 33%

Biochemistry, Genetics and Molecular Biology

• Cyclic Adenosine Monophosphate 100%
• G Protein Coupled Receptor 100%
• Calcitonin Receptor 100%
• Calcitonin Gene Related Peptide 100%
• RAMP1 66%
• Ligand Binding 33%
• Adenylate Cyclase 33%
• Binding Site 33%
• Cell Surface Receptor 33%
• Alanine 33%
• Leucine 33%
• Signal Transduction 33%
• Transmembrane Domain 33%
• Rhodopsin 33%
• Internalization 33%
• Secretin 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Calcitonin Gene Related Peptide Receptor 100%
• G Protein Coupled Receptor 100%
• Calcitonin Receptor Like Receptor 100%
• Receptor Activity Modifying Protein 1 66%
• Adenylate Cyclase 33%
• Binding Site 33%
• Drug Development 33%
• Leucine 33%
• Cell Surface Receptor 33%
• Alanine 33%
• Rhodopsin 33%
• Secretin 33%