Eye movement analysis in congenital nystagmus

concise parameters estimation

Giulio Pasquariello, Mario Cesarelli, Antonio la Gatta, Paolo Bifulco, Antonio Fratini

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Along with other diseases that can affect binocular vision, reducing the visual quality of a subject, Congenital Nystagmus (CN) is of peculiar interest. CN is an ocular-motor disorder characterized by involuntary, conjugated ocular oscillations and, while identified more than forty years ago, its pathogenesis is still under investigation. This kind of nystagmus is termed congenital (or infantile) since it could be present at birth or it can arise in the first months of life. The majority of CN patients show a considerable decrease of their visual acuity: image fixation on the retina is disturbed by nystagmus continuous oscillations, mainly horizontal. However, the image of a given target can still be stable during short periods in which eye velocity slows down while the target image is placed onto the fovea (called foveation intervals). To quantify the extent of nystagmus, eye movement recordings are routinely employed, allowing physicians to extract and analyze nystagmus main features such as waveform shape, amplitude and frequency. Use of eye movement recording, opportunely processed, allows computing "estimated visual acuity" predictors, which are analytical functions that estimate expected visual acuity using signal features such as foveation time and foveation position variability. Hence, it is fundamental to develop robust and accurate methods to measure both those parameters in order to obtain reliable values from the predictors. In this chapter the current methods to record eye movements in subjects with congenital nystagmus will be discussed and the present techniques to accurately compute foveation time and eye position will be presented. This study aims to disclose new methodologies in congenital nystagmus eye movements analysis, in order to identify nystagmus cycles and to evaluate foveation time, reducing the influence of repositioning saccades and data noise on the critical parameters of the estimation functions. Use of those functions extends the information acquired with typical visual acuity measurement (e.g., Landolt C test) and could be a support for treatment planning or therapy monitoring.

Original languageEnglish
Title of host publicationBinocular vision
Subtitle of host publicationdevelopment, depth perception and disorders
EditorsJacques McCoun, Lucien Reeves
PublisherNova science
Pages107-123
Number of pages17
ISBN (Electronic)978-1-61761-957-1
ISBN (Print)978-1-60876-547-8
Publication statusPublished - Jan 2013

Publication series

NameEye and vision research developments
PublisherNova

Fingerprint

Congenital Nystagmus
Eye Movements
Visual Acuity
Binocular Vision
Saccades
Noise
Retina
Parturition
Physicians
Therapeutics

Cite this

Pasquariello, G., Cesarelli, M., la Gatta, A., Bifulco, P., & Fratini, A. (2013). Eye movement analysis in congenital nystagmus: concise parameters estimation. In J. McCoun, & L. Reeves (Eds.), Binocular vision: development, depth perception and disorders (pp. 107-123). (Eye and vision research developments). Nova science.
Pasquariello, Giulio ; Cesarelli, Mario ; la Gatta, Antonio ; Bifulco, Paolo ; Fratini, Antonio. / Eye movement analysis in congenital nystagmus : concise parameters estimation. Binocular vision: development, depth perception and disorders. editor / Jacques McCoun ; Lucien Reeves. Nova science, 2013. pp. 107-123 (Eye and vision research developments).
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Pasquariello, G, Cesarelli, M, la Gatta, A, Bifulco, P & Fratini, A 2013, Eye movement analysis in congenital nystagmus: concise parameters estimation. in J McCoun & L Reeves (eds), Binocular vision: development, depth perception and disorders. Eye and vision research developments, Nova science, pp. 107-123.

Eye movement analysis in congenital nystagmus : concise parameters estimation. / Pasquariello, Giulio; Cesarelli, Mario; la Gatta, Antonio; Bifulco, Paolo; Fratini, Antonio.

Binocular vision: development, depth perception and disorders. ed. / Jacques McCoun; Lucien Reeves. Nova science, 2013. p. 107-123 (Eye and vision research developments).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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AU - Fratini, Antonio

PY - 2013/1

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N2 - Along with other diseases that can affect binocular vision, reducing the visual quality of a subject, Congenital Nystagmus (CN) is of peculiar interest. CN is an ocular-motor disorder characterized by involuntary, conjugated ocular oscillations and, while identified more than forty years ago, its pathogenesis is still under investigation. This kind of nystagmus is termed congenital (or infantile) since it could be present at birth or it can arise in the first months of life. The majority of CN patients show a considerable decrease of their visual acuity: image fixation on the retina is disturbed by nystagmus continuous oscillations, mainly horizontal. However, the image of a given target can still be stable during short periods in which eye velocity slows down while the target image is placed onto the fovea (called foveation intervals). To quantify the extent of nystagmus, eye movement recordings are routinely employed, allowing physicians to extract and analyze nystagmus main features such as waveform shape, amplitude and frequency. Use of eye movement recording, opportunely processed, allows computing "estimated visual acuity" predictors, which are analytical functions that estimate expected visual acuity using signal features such as foveation time and foveation position variability. Hence, it is fundamental to develop robust and accurate methods to measure both those parameters in order to obtain reliable values from the predictors. In this chapter the current methods to record eye movements in subjects with congenital nystagmus will be discussed and the present techniques to accurately compute foveation time and eye position will be presented. This study aims to disclose new methodologies in congenital nystagmus eye movements analysis, in order to identify nystagmus cycles and to evaluate foveation time, reducing the influence of repositioning saccades and data noise on the critical parameters of the estimation functions. Use of those functions extends the information acquired with typical visual acuity measurement (e.g., Landolt C test) and could be a support for treatment planning or therapy monitoring.

AB - Along with other diseases that can affect binocular vision, reducing the visual quality of a subject, Congenital Nystagmus (CN) is of peculiar interest. CN is an ocular-motor disorder characterized by involuntary, conjugated ocular oscillations and, while identified more than forty years ago, its pathogenesis is still under investigation. This kind of nystagmus is termed congenital (or infantile) since it could be present at birth or it can arise in the first months of life. The majority of CN patients show a considerable decrease of their visual acuity: image fixation on the retina is disturbed by nystagmus continuous oscillations, mainly horizontal. However, the image of a given target can still be stable during short periods in which eye velocity slows down while the target image is placed onto the fovea (called foveation intervals). To quantify the extent of nystagmus, eye movement recordings are routinely employed, allowing physicians to extract and analyze nystagmus main features such as waveform shape, amplitude and frequency. Use of eye movement recording, opportunely processed, allows computing "estimated visual acuity" predictors, which are analytical functions that estimate expected visual acuity using signal features such as foveation time and foveation position variability. Hence, it is fundamental to develop robust and accurate methods to measure both those parameters in order to obtain reliable values from the predictors. In this chapter the current methods to record eye movements in subjects with congenital nystagmus will be discussed and the present techniques to accurately compute foveation time and eye position will be presented. This study aims to disclose new methodologies in congenital nystagmus eye movements analysis, in order to identify nystagmus cycles and to evaluate foveation time, reducing the influence of repositioning saccades and data noise on the critical parameters of the estimation functions. Use of those functions extends the information acquired with typical visual acuity measurement (e.g., Landolt C test) and could be a support for treatment planning or therapy monitoring.

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M3 - Chapter (peer-reviewed)

SN - 978-1-60876-547-8

T3 - Eye and vision research developments

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Pasquariello G, Cesarelli M, la Gatta A, Bifulco P, Fratini A. Eye movement analysis in congenital nystagmus: concise parameters estimation. In McCoun J, Reeves L, editors, Binocular vision: development, depth perception and disorders. Nova science. 2013. p. 107-123. (Eye and vision research developments).